Version history

{
  "scope": "mouse PFC/frontal cortex",
  "claim_text": "Since PV interneurons do not express the requisite β2 subunit to form a functional α5-containing nAChR, these results may be due to the expression of the α5 subunit in either VIP or SOM interneurons.",
  "raw_fields": {
    "n": null,
    "doi": "10.1038/nm.4274",
    "year": "2017",
    "claim": "Since PV interneurons do not express the requisite β2 subunit to form a functional α5-containing nAChR, these results may be due to the expression of the α5 subunit in either VIP or SOM interneurons.",
    "title": null,
    "journal": "Nature medicine",
    "cite_key": "Koukouli2017",
    "evidence": "Nicotine reverses hypofrontality in animal models of addiction and schizophrenia",
    "effect_size": "2.9% of",
    "text_access": "fulltext",
    "first_author": "Koukouli",
    "study_system": "mouse PFC/frontal cortex",
    "_source_cluster": "cluster_06_disinhibition_circuit",
    "author_list_short": "Koukouli, Rooy, Tziotis",
    "replication_status": "replicated",
    "_source_cluster_index": 24,
    "claim_source_sentence": "Since PV interneurons do not express the requisite β2 subunit to form a functional α5-containing nAChR, these results may be due to the expression of the α5 subunit in either VIP or SOM interneurons.",
    "replication_evidence_dois": [
      "10.1038/nn.4002",
      "10.1038/s41467-019-13244-9"
    ],
    "effect_size_source_sentence": "Wild-type (WT) mice exhibited a clear preference for a novel social partner, spending 69.6 ± 2.9% of their time engaged in social interaction, while α5SNP littermates showed no preference between the social partner and an inanimate object (44.1 ± 5.3%) ( Fig."
  },
  "section_id": "section_13",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_13_evidence_package.json",
  "effect_size": "2.9% of",
  "review_repo": "ComputationalReviewVIP",
  "section_ref": "wiki_page:computationalreviewvip-13-conclusion",
  "source_kind": "review_finding",
  "source_path": "evidence/section_13_evidence_package.json",
  "source_refs": [
    "paper:paper-9f4aa2a403bd"
  ],
  "source_span": "Since PV interneurons do not express the requisite β2 subunit to form a functional α5-containing nAChR, these results may be due to the expression of the α5 subunit in either VIP or SOM interneurons.",
  "study_system": "mouse PFC/frontal cortex",
  "evidence_refs": [
    {
      "ref": "paper:paper-9f4aa2a403bd"
    }
  ],
  "section_title": "Synthesis and Conclusion: Reassessing the Canonical VIP Disinhibitor",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
  },
  "evidence_summary": "Nicotine reverses hypofrontality in animal models of addiction and schizophrenia",
  "review_bundle_ref": "analysis_bundle:ab-2ce40c33e827",
  "replication_status": "replicated",
  "review_package_ref": "analysis_bundle:ab-2ce40c33e827",
  "source_artifact_ref": "wiki_page:computationalreviewvip-13-conclusion",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_13_evidence_package.json",
  "commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
}