Version history

{
  "scope": "Principles of connectivity among morphologically defined cell types in adult neocortex.",
  "claim_text": "Jiang/Tolias 2015 Science — octuple whole-cell paired recordings, mouse V1, principles of connectivity by morphological cell type across L1/L2/3/L5; foundational large-scale paired-recording dataset.",
  "raw_fields": {
    "n": null,
    "doi": "10.1126/science.aac9462",
    "claim": "Jiang/Tolias 2015 Science — octuple whole-cell paired recordings, mouse V1, principles of connectivity by morphological cell type across L1/L2/3/L5; foundational large-scale paired-recording dataset.",
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    "evidence": "Since the work of Ramón y Cajal in the late 19th and early 20th centuries, neuroscientists have speculated that a complete understanding of neuronal cell types and their connections is key to explaining complex brain functions. However, a complete census of the constituent cell types and their wiring diagram in mature neocortex remains elusive. By combining octuple whole-cell recordings with an optimized avidin-biotin-peroxidase staining technique, we carried out a morphological and electrophysiological census of neuronal types in layers 1, 2/3, and 5 of mature neocortex and mapped the connectivity between more than 11,000 pairs of identified neurons. We categorized 15 types of interneurons, and each exhibited a characteristic pattern of connectivity with other interneuron types and pyramidal cells. The essential connectivity structure of the neocortical microcircuit could be captured by only a few connectivity motifs.",
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    "claim_source_sentence": "By combining octuple whole-cell recordings with an optimized avidin-biotin-peroxidase staining technique, we carried out a morphological and electrophysiological census of neuronal types in layers 1, 2/3, and 5 of mature neocortex and mapped the co[nnectivity among them].",
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  "section_id": "section_03",
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  "source_span": "By combining octuple whole-cell recordings with an optimized avidin-biotin-peroxidase staining technique, we carried out a morphological and electrophysiological census of neuronal types in layers 1, 2/3, and 5 of mature neocortex and mapped the co[nnectivity among them].",
  "study_system": "Principles of connectivity among morphologically defined cell types in adult neocortex.",
  "evidence_refs": [
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  ],
  "section_title": "3. Paired-recording evidence in mouse — connection probabilities and synaptic strengths between pyramidal cells within a column, layer-by-layer (Lefort, Petersen, Adesnik, Feldmeyer, Markram-style work in mouse)",
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      "Local review repositories are read-only inputs.",
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  "evidence_summary": "Since the work of Ramón y Cajal in the late 19th and early 20th centuries, neuroscientists have speculated that a complete understanding of neuronal cell types and their connections is key to explaining complex brain functions. However, a complete census of the constituent cell types and their wiring diagram in mature neocortex remains elusive. By combining octuple whole-cell recordings with an optimized avidin-biotin-peroxidase staining technique, we carried out a morphological and electrophysiological census of neuronal types in layers 1, 2/3, and 5 of mature neocortex and mapped the connectivity between more than 11,000 pairs of identified neurons. We categorized 15 types of interneurons, and each exhibited a characteristic pattern of connectivity with other interneuron types and pyramidal cells. The essential connectivity structure of the neocortical microcircuit could be captured by only a few connectivity motifs.",
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  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_03_evidence_package.json",
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}