In mouse V1, individual L2/3 pyramidal neurons receive functionally diverse syn…

In mouse V1, individual L2/3 pyramidal neurons receive functionally diverse synaptic inputs spanning visual space, with long-range inputs from distant retinotopic locations preferentially shared orientation preference with the postsynaptic neuron when displaced along the neuron's preferred orientation axis — indicating a co-axial (collinear) excitatory-input wiring rule in rodent V1 despite the lack of orientation columns.

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  "doi": "10.1038/nature23019",
  "claim": "In mouse V1, individual L2/3 pyramidal neurons receive functionally diverse synaptic inputs spanning visual space, with long-range inputs from distant retinotopic locations preferentially shared orientation preference with the postsynaptic neuron when displaced along the neuron's preferred orientation axis — indicating a co-axial (collinear) excitatory-input wiring rule in rodent V1 despite the lack of orientation columns.",
  "cite_key": "Iacaruso2017",
  "evidence": "Dendritic-spine two-photon calcium imaging of receptive fields in mouse V1 L2/3 pyramidal neurons with mapping of spine-vs-soma RF displacement and orientation similarity.",
  "effect_size": "qualitative — co-axial RF-displaced inputs preferentially share orientation preference",
  "text_access": "fulltext",
  "study_system": "adult mouse primary visual cortex (V1), L2/3 pyramidal dendritic spines",
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  "claim_source_sentence": "These putative long-range inputs were more frequent and more likely to share the preference for oriented edges with the postsynaptic neuron when the input's receptive field was spatially displaced along the axis of the postsynaptic neuron's receptive field orientation",
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  "replication_evidence_dois": [
    "10.1038/nature14182"
  ],
  "effect_size_source_sentence": "more likely to share the preference for oriented edges with the postsynaptic neuron when the input's receptive field was spatially displaced along the axis of the postsynaptic neuron's receptive field orientation"
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These putative long-range inputs were more frequent and more likely to share the preference for oriented edges with the postsynaptic neuron when the input's receptive field was spatially displaced along the axis of the postsynaptic neuron's receptive field orientation

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