PVBCs evoke more reliable unitary IPSCs in pyramidal neurons than CCKBCs, but P…

{
  "n": 35,
  "doi": "10.1113/jp286284",
  "claim": "PVBCs evoke more reliable unitary IPSCs in pyramidal neurons than CCKBCs, but PVBC connections show profound short-term depression",
  "evidence": "Paired recordings in mouse mPFC; PVBCs also receive larger unitary EPSCs from PNs with shorter latency and faster kinetics compared to CCKBCs",
  "effect_size": "Investigation of the short‐term dynamics in these inhibitory synapses with the same protocol described above revealed that synapses arriving from PVBCs onto PNs showed significant short‐term depression (second and fifth uIPSC amplitude decreased to 71.4 ± 3.4% and 46.27 ± 2.62% of the first response",
  "text_access": "fulltext",
  "study_system": "mouse medial prefrontal cortex, paired recordings",
  "replication_status": "independently_replicated",
  "claim_source_sentence": "unitary inhibitory postsynaptic currents in PNs were more reliably evoked by PVBCs than by CCKBCs, yet the former connections showed profound short-term depression.",
  "replication_evidence_dois": [
    "10.1152/jn.00167.2014",
    "10.1111/j.1460-9568.2010.07292.x"
  ],
  "effect_size_source_sentence": "Investigation of the short‐term dynamics in these inhibitory synapses with the same protocol described above revealed that synapses arriving from PVBCs onto PNs showed significant short‐term depression (second and fifth uIPSC amplitude decreased to 71.4 ± 3.4% and 46.27 ± 2.62% of the first response), a phenomenon previously observed in other cortical regions as well (Barsy et al., 2017 ; Galarret"
}

Investigation of the short‐term dynamics in these inhibitory synapses with the same protocol described above revealed that synapses arriving from PVBCs onto PNs showed significant short‐term depression (second and fifth uIPSC amplitude decreased to 71.4 ± 3.4% and 46.27 ± 2.62% of the first response

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]

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