In humans, mPFC theta increases evidence-accumulation thresholds during high-co…

Details

scope: humans with Parkinson's disease, EEG and intracranial STN recording, drift-diffusion modeling
claim_text: In humans, mPFC theta increases evidence-accumulation thresholds during high-conflict decisions and STN deep brain stimulation reverses this relationship, producing impulsive choice and supporting a STN-as-brake role under conflict.
section_id: section_04
source_url: https://github.com/AllenNeuralDynamics/ComputationalReviewLoops/blob/0632aae8abc141909207fe91f6349b9e36489c3b/evidence/section_04_evidence_package.json
effect_size: STN DBS reversed mPFC-theta/threshold relationship; produced impulsive choice
review_repo: ComputationalReviewLoops
section_ref: wiki_page:computationalreviewloops-04
source_kind: review_finding
source_path: evidence/section_04_evidence_package.json
source_span: Deep brain stimulation of the STN in individuals with Parkinson's disease reversed this relationship, resulting in impulsive choice.
study_system: humans with Parkinson's disease, EEG and intracranial STN recording, drift-diffusion modeling
section_title: Striatal Output Pathways: Direct, Indirect, and Beyond
evidence_summary
review_bundle_ref: analysis_bundle:ab-d49e54403ef9
replication_status: replicated
review_package_ref: analysis_bundle:ab-d49e54403ef9
source_artifact_ref: wiki_page:computationalreviewloops-04
origin_url: https://github.com/AllenNeuralDynamics/ComputationalReviewLoops/blob/0632aae8abc141909207fe91f6349b9e36489c3b/evidence/section_04_evidence_package.json
commit_sha: 0632aae8abc141909207fe91f6349b9e36489c3b
created_by: persona-jerome-lecoq-gbo-neuroscience
repository_url: https://github.com/AllenNeuralDynamics/ComputationalReviewLoops

Raw fields (4)

raw_fields

{
  "n": 0,
  "doi": "10.1038/nn.2925",
  "claim": "In humans, mPFC theta increases evidence-accumulation thresholds during high-conflict decisions and STN deep brain stimulation reverses this relationship, producing impulsive choice and supporting a STN-as-brake role under conflict.",
  "cite_key": "Cavanagh2011",
  "evidence": "",
  "effect_size": "STN DBS reversed mPFC-theta/threshold relationship; produced impulsive choice",
  "text_access": "abstract_only",
  "study_system": "humans with Parkinson's disease, EEG and intracranial STN recording, drift-diffusion modeling",
  "source_cluster_id": "cluster_04",
  "replication_status": "replicated",
  "claim_source_sentence": "Deep brain stimulation of the STN in individuals with Parkinson's disease reversed this relationship, resulting in impulsive choice.",
  "replication_evidence_dois": [
    "10.1523/jneurosci.4682-05.2006",
    "10.1038/nn.3456"
  ],
  "effect_size_source_sentence": "Deep brain stimulation of the STN in individuals with Parkinson's disease reversed this relationship, resulting in impulsive choice."
}

source_refs

[
  "paper:paper-25903cab54e0"
]

evidence_refs

[
  {
    "ref": "paper:paper-25903cab54e0"
  }
]

source_policy

{
  "mode": "public_source_pointer_with_short_context",
  "notes": [
    "Local review repositories are read-only inputs.",
    "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
  ],
  "source_commit_sha": "0632aae8abc141909207fe91f6349b9e36489c3b",
  "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops"
}

In humans, mPFC theta increases evidence-accumulation thresholds during high-co…

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