Version history

{
  "scope": "mouse auditory and medial prefrontal cortex, in vivo and in vitro",
  "claim_text": "VIP interneurons mediate disinhibitory control by suppressing primarily SOM and a fraction of PV interneurons, creating a specific cell-type-based disinhibitory circuit module in cortex",
  "raw_fields": {
    "n": 0,
    "doi": "10.1038/nature12676",
    "claim": "VIP interneurons mediate disinhibitory control by suppressing primarily SOM and a fraction of PV interneurons, creating a specific cell-type-based disinhibitory circuit module in cortex",
    "evidence": "Optogenetic activation combined with single cell recordings in awake mice in auditory and medial prefrontal cortices",
    "effect_size": "VIP recruitment increased the gain of a functional subpopulation of principal neurons during auditory discrimination task",
    "text_access": "fulltext",
    "study_system": "mouse auditory and medial prefrontal cortex, in vivo and in vitro",
    "replication_status": "independently replicated",
    "claim_source_sentence": "We identified a basic disinhibitory circuit module in which activation of VIP interneurons transiently suppresses primarily somatostatin- and a fraction of parvalbumin-expressing inhibitory interneurons that specialize in the control of the input and output of principal cells, respectively.",
    "replication_evidence_dois": [
      "10.7554/elife.14985",
      "10.1016/j.neuron.2019.07.027"
    ],
    "effect_size_source_sentence": "During the performance of an auditory discrimination task, reinforcement signals (reward and punishment) strongly and uniformly activated VIP neurons in auditory cortex, and in turn VIP recruitment increased the gain of a functional subpopulation of principal neurons."
  },
  "section_id": "section_07_evidence_package",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_07_evidence_package.json",
  "effect_size": "VIP recruitment increased the gain of a functional subpopulation of principal neurons during auditory discrimination task",
  "review_repo": "ComputationalReviewPV",
  "section_ref": "wiki_page:computationalreviewpv-07",
  "source_kind": "review_finding",
  "source_path": "evidence/section_07_evidence_package.json",
  "source_refs": [
    "paper:paper-065a0eae69a5"
  ],
  "source_span": "We identified a basic disinhibitory circuit module in which activation of VIP interneurons transiently suppresses primarily somatostatin- and a fraction of parvalbumin-expressing inhibitory interneurons that specialize in the control of the input and output of principal cells, respectively.",
  "study_system": "mouse auditory and medial prefrontal cortex, in vivo and in vitro",
  "evidence_refs": [
    {
      "ref": "paper:paper-065a0eae69a5"
    }
  ],
  "section_title": "Local Circuit Motifs: Perisomatic Inhibition, Feedback, and Feedforward",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "df9fc7e8d455b084152c9d713558dae0013cef21",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV"
  },
  "evidence_summary": "Optogenetic activation combined with single cell recordings in awake mice in auditory and medial prefrontal cortices",
  "review_bundle_ref": "analysis_bundle:ab-e6261c8263e7",
  "replication_status": "independently replicated",
  "review_package_ref": "analysis_bundle:ab-e6261c8263e7",
  "source_artifact_ref": "wiki_page:computationalreviewpv-07",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_07_evidence_package.json",
  "commit_sha": "df9fc7e8d455b084152c9d713558dae0013cef21",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV"
}