Details

scope
mice, miniscope and bulk recordings of D1/D2 SPNs in DLS during spontaneous behavior
claim_text
In dorsolateral striatum, direct- and indirect-pathway activity encodes the identity and ordering of sub-second 3D behavioral motifs, with fast-timescale decorrelations between pathways supporting this code.
section_id
section_04
source_url
https://github.com/AllenNeuralDynamics/ComputationalReviewLoops/blob/0632aae8abc141909207fe91f6349b9e36489c3b/evidence/section_04_evidence_package.json
effect_size
sub-second decorrelations between direct/indirect pathway activity encode 3D motifs
review_repo
ComputationalReviewLoops
section_ref
wiki_page:computationalreviewloops-04
source_kind
review_finding
source_path
evidence/section_04_evidence_package.json
source_span
Focal lesions of the DLS alter the sequencing of these hand-annotated patterns of action, demonstrating a causal role for the striatum in controlling the sequential structure of at least some behaviors ( Berridge and Fentress, 1987 ).
study_system
mice, miniscope and bulk recordings of D1/D2 SPNs in DLS during spontaneous behavior
section_title
Striatal Output Pathways: Direct, Indirect, and Beyond
evidence_summary
review_bundle_ref
analysis_bundle:ab-d49e54403ef9
replication_status
replicated
review_package_ref
analysis_bundle:ab-d49e54403ef9
source_artifact_ref
wiki_page:computationalreviewloops-04
origin_url
https://github.com/AllenNeuralDynamics/ComputationalReviewLoops/blob/0632aae8abc141909207fe91f6349b9e36489c3b/evidence/section_04_evidence_package.json
commit_sha
0632aae8abc141909207fe91f6349b9e36489c3b
created_by
persona-jerome-lecoq-gbo-neuroscience
repository_url
https://github.com/AllenNeuralDynamics/ComputationalReviewLoops
Raw fields (4)
raw_fields
{
  "n": 0,
  "doi": "10.1016/j.cell.2018.04.019",
  "claim": "In dorsolateral striatum, direct- and indirect-pathway activity encodes the identity and ordering of sub-second 3D behavioral motifs, with fast-timescale decorrelations between pathways supporting this code.",
  "cite_key": "Markowitz2018",
  "evidence": "",
  "effect_size": "sub-second decorrelations between direct/indirect pathway activity encode 3D motifs",
  "text_access": "fulltext",
  "study_system": "mice, miniscope and bulk recordings of D1/D2 SPNs in DLS during spontaneous behavior",
  "source_cluster_id": "cluster_04",
  "replication_status": "replicated",
  "claim_source_sentence": "Focal lesions of the DLS alter the sequencing of these hand-annotated patterns of action, demonstrating a causal role for the striatum in controlling the sequential structure of at least some behaviors ( Berridge and Fentress, 1987 ).",
  "replication_evidence_dois": [
    "10.1038/nature11846",
    "10.1016/j.neuron.2017.08.015"
  ],
  "effect_size_source_sentence": "These experiments reveal that DLS neurons systematically encode information about the identity and ordering of sub-second 3D behavioral motifs; this encoding is facilitated by fast-timescale decorrelations between the direct and indirect pathways."
}
source_refs
[
  "paper:paper-940c58205112"
]
evidence_refs
[
  {
    "ref": "paper:paper-940c58205112"
  }
]
source_policy
{
  "mode": "public_source_pointer_with_short_context",
  "notes": [
    "Local review repositories are read-only inputs.",
    "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
  ],
  "source_commit_sha": "0632aae8abc141909207fe91f6349b9e36489c3b",
  "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops"
}

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