Version history

{
  "scope": "mouse barrel cortex L4, postmitotic Lhx2 conditional knockout",
  "claim_text": "Conditional deletion of Lhx2 in postmitotic mouse cortical neurons preserves initial L4 specification but blocks barrel formation and L4 dendritic polarization; thalamocortical axons reach the barrel cortex but fail to arborize, and Lhx2 directly induces Btbd3 to confer activity-dependent dendritic competence for L4 circuit assembly.",
  "raw_fields": {
    "n": null,
    "doi": "10.1016/j.celrep.2017.01.001",
    "claim": "Conditional deletion of Lhx2 in postmitotic mouse cortical neurons preserves initial L4 specification but blocks barrel formation and L4 dendritic polarization; thalamocortical axons reach the barrel cortex but fail to arborize, and Lhx2 directly induces Btbd3 to confer activity-dependent dendritic competence for L4 circuit assembly.",
    "cite_key": "Wang2017c",
    "evidence": "Postmitotic-cortical-neuron-specific Lhx2 conditional knockout mice with anatomy of barrels, thalamocortical-axon tracing and downstream-target Btbd3 analysis.",
    "effect_size": null,
    "text_access": "abstract_only",
    "study_system": "mouse barrel cortex L4, postmitotic Lhx2 conditional knockout",
    "argument_role": "supporting",
    "replication_status": "replication_unknown",
    "claim_source_sentence": "When Lhx2 is selectively deleted in postmitotic cortical neurons using conditional knockout (cKO) mice, L4 neurons in the barrel cortex are initially specified but fail to form cellular barrels or develop polarized dendrites. In Lhx2 cKO mice, TCAs from the thalamic ventral posterior nucleus reach the barrel cortex but fail to further arborize to form barrels.",
    "source_provenance_status": "non_substring_match",
    "replication_evidence_dois": [],
    "effect_size_source_sentence": null
  },
  "section_id": "section_01",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_01_evidence_package.json",
  "effect_size": null,
  "review_repo": "ComputationalReviewRecurrence",
  "section_ref": "wiki_page:computationalreviewrecurrence-01-introduction",
  "source_kind": "review_finding",
  "source_path": "evidence/section_01_evidence_package.json",
  "source_refs": [
    "paper:paper-c24689e3cc1f"
  ],
  "source_span": "When Lhx2 is selectively deleted in postmitotic cortical neurons using conditional knockout (cKO) mice, L4 neurons in the barrel cortex are initially specified but fail to form cellular barrels or develop polarized dendrites. In Lhx2 cKO mice, TCAs from the thalamic ventral posterior nucleus reach the barrel cortex but fail to further arborize to form barrels.",
  "study_system": "mouse barrel cortex L4, postmitotic Lhx2 conditional knockout",
  "evidence_refs": [
    {
      "ref": "paper:paper-c24689e3cc1f"
    }
  ],
  "section_title": "1. Introduction — what \"excitatory recurrence\" means operationally in mouse cortex, and why isolating it from inhibition and from clinical framings is a defensible analytic move for basic-research synthesis",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
  },
  "evidence_summary": "Postmitotic-cortical-neuron-specific Lhx2 conditional knockout mice with anatomy of barrels, thalamocortical-axon tracing and downstream-target Btbd3 analysis.",
  "review_bundle_ref": "analysis_bundle:ab-d9c479db9be9",
  "replication_status": "replication_unknown",
  "review_package_ref": "analysis_bundle:ab-d9c479db9be9",
  "source_artifact_ref": "wiki_page:computationalreviewrecurrence-01-introduction",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_01_evidence_package.json",
  "commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
}