Version history

{
  "scope": "mouse, Nkx2-1 cKO, ChIP-seq at E13.5",
  "claim_text": "NKX2-1 operates through both transcriptional repression (defining MGE identity) and activation (via LHX6/LHX8 for GABAergic/cholinergic fates)",
  "raw_fields": {
    "n": 0,
    "doi": "10.1186/s13064-018-0119-4",
    "claim": "NKX2-1 operates through both transcriptional repression (defining MGE identity) and activation (via LHX6/LHX8 for GABAergic/cholinergic fates)",
    "evidence": "ChIP-seq identified 4782 activating and 6391 repressing regulatory elements in Nkx2-1 cKO; activating REs associated with bHLH transcription factors",
    "effect_size": "4782 activating REs and 6391 repressing REs",
    "text_access": "fulltext",
    "study_system": "mouse, Nkx2-1 cKO, ChIP-seq at E13.5",
    "replication_status": "independently_replicated",
    "claim_source_sentence": "NKX2–1 defines MGE regional identity in large part through transcriptional repression, while specification and maturation of GABAergic and cholinergic fates is mediated in part by transcriptional activation via TFs such as LHX6 and LHX8.",
    "replication_evidence_dois": [
      "10.1016/j.neuron.2014.02.030",
      "10.1523/jneurosci.3496-17.2018"
    ],
    "effect_size_source_sentence": "We identified 4782 activating REs (aREs) and 6391 repressing REs (rREs) in the Nkx2–1 conditional knockout (Nkx2–1 cKO) MGE."
  },
  "section_id": "section_03_evidence_package",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_03_evidence_package.json",
  "effect_size": "4782 activating REs and 6391 repressing REs",
  "review_repo": "ComputationalReviewPV",
  "section_ref": "wiki_page:computationalreviewpv-03",
  "source_kind": "review_finding",
  "source_path": "evidence/section_03_evidence_package.json",
  "source_refs": [
    "paper:paper-5446828ba9e0"
  ],
  "source_span": "NKX2–1 defines MGE regional identity in large part through transcriptional repression, while specification and maturation of GABAergic and cholinergic fates is mediated in part by transcriptional activation via TFs such as LHX6 and LHX8.",
  "study_system": "mouse, Nkx2-1 cKO, ChIP-seq at E13.5",
  "evidence_refs": [
    {
      "ref": "paper:paper-5446828ba9e0"
    }
  ],
  "section_title": "Developmental Origins: MGE Lineage, Specification, and Migration",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "df9fc7e8d455b084152c9d713558dae0013cef21",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV"
  },
  "evidence_summary": "ChIP-seq identified 4782 activating and 6391 repressing regulatory elements in Nkx2-1 cKO; activating REs associated with bHLH transcription factors",
  "review_bundle_ref": "analysis_bundle:ab-e6261c8263e7",
  "replication_status": "independently_replicated",
  "review_package_ref": "analysis_bundle:ab-e6261c8263e7",
  "source_artifact_ref": "wiki_page:computationalreviewpv-03",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_03_evidence_package.json",
  "commit_sha": "df9fc7e8d455b084152c9d713558dae0013cef21",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV"
}