To characterize the molecular identity of these LRG neurons, we injected a retr…

Details

scope: mammal PFC/frontal cortex/hippocampus
section_id: section_01
source_url: https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_01_evidence_package.json
review_repo: ComputationalReviewVIP
section_ref: wiki_page:computationalreviewvip-01-introduction
source_kind: review_finding
source_path: evidence/section_01_evidence_package.json
study_system: mammal PFC/frontal cortex/hippocampus
section_title: Introduction
evidence_summary: Top-down control of hippocampal signal-to-noise by prefrontal long-range inhibition
review_bundle_ref: analysis_bundle:ab-2ce40c33e827
replication_status: replication_unknown
review_package_ref: analysis_bundle:ab-2ce40c33e827
source_artifact_ref: wiki_page:computationalreviewvip-01-introduction
origin_url: https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_01_evidence_package.json
commit_sha: 95e761177f7d2ec565983d3307c14ec238f9677c
created_by: persona-jerome-lecoq-gbo-neuroscience
repository_url: https://github.com/AllenNeuralDynamics/ComputationalReviewVIP

Raw fields (6)

claim_text

To characterize the molecular identity of these LRG neurons, we injected a retrograde tracer (Alexa 594-tagged CTb) in dHPC and performed immunohistochemistry in prefrontal sections ( Figures S1 C and S1D). dHPC-projecting PFC LRG neurons include parvalbumin (PV), somatostatin (SST), and vasoactive intestinal polypeptide (VIP)-expressing subpopulations, as well as small percentages of calretinin (CR) and neuropeptide-Y (NPY) expressing neurons ( Figures S1 E and S1F).

raw_fields

{
  "n": 8,
  "doi": "10.1016/j.cell.2022.04.001",
  "year": "2022",
  "claim": "To characterize the molecular identity of these LRG neurons, we injected a retrograde tracer (Alexa 594-tagged CTb) in dHPC and performed immunohistochemistry in prefrontal sections ( Figures S1 C and S1D). dHPC-projecting PFC LRG neurons include parvalbumin (PV), somatostatin (SST), and vasoactive intestinal polypeptide (VIP)-expressing subpopulations, as well as small percentages of calretinin (CR) and neuropeptide-Y (NPY) expressing neurons ( Figures S1 E and S1F).",
  "title": null,
  "journal": "Cell",
  "cite_key": "Malik2022",
  "evidence": "Top-down control of hippocampal signal-to-noise by prefrontal long-range inhibition",
  "effect_size": null,
  "text_access": "fulltext",
  "first_author": "Malik",
  "study_system": "mammal PFC/frontal cortex/hippocampus",
  "_source_cluster": "cluster_06_disinhibition_circuit",
  "author_list_short": "Malik, Li, Schamiloglu",
  "replication_status": "replication_unknown",
  "_source_cluster_index": 33,
  "claim_source_sentence": "To characterize the molecular identity of these LRG neurons, we injected a retrograde tracer (Alexa 594-tagged CTb) in dHPC and performed immunohistochemistry in prefrontal sections ( Figures S1 C and S1D). dHPC-projecting PFC LRG neurons include parvalbumin (PV), somatostatin (SST), and vasoactive intestinal polypeptide (VIP)-expressing subpopulations, as well as small percentages of calretinin (CR) and neuropeptide-Y (NPY) expressing neurons ( Figures S1 E and S1F).",
  "replication_evidence_dois": [],
  "effect_size_source_sentence": "Open circles represent data from individual neurons (n = 8) and bars represent averages; one-way ANOVA followed by Tukey’s multiple comparison test, ∗∗∗ p &lt; 0.001. (E) Schematic of the intersectional strategy to label dHPC-projecting PFC LRG neurons. (F) Representative images showing ChR2-eYFP-expressing, dHPC-projecting PFC LRG neurons."
}

source_refs

[
  "paper:paper-f83cd6e11b6c"
]

source_span

To characterize the molecular identity of these LRG neurons, we injected a retrograde tracer (Alexa 594-tagged CTb) in dHPC and performed immunohistochemistry in prefrontal sections ( Figures S1 C and S1D). dHPC-projecting PFC LRG neurons include parvalbumin (PV), somatostatin (SST), and vasoactive intestinal polypeptide (VIP)-expressing subpopulations, as well as small percentages of calretinin (CR) and neuropeptid...

evidence_refs

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    "ref": "paper:paper-f83cd6e11b6c"
  }
]

source_policy

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  "notes": [
    "Local review repositories are read-only inputs.",
    "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
  ],
  "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
  "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
}

To characterize the molecular identity of these LRG neurons, we injected a retr…

Details

Replication

Discussion