Mouse S1↔M1 long-range corticocortical E synapses facilitate, contrasting with…

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  "n": null,
  "doi": "10.1093/cercor/bhab325",
  "claim": "Mouse S1↔M1 long-range corticocortical E synapses facilitate, contrasting with the prevalent short-term depression of local L2/3↔L2/3 and L5↔L5 connections.",
  "cite_key": "Martinetti2022",
  "evidence": "Short-term plasticity regulates the strength of central synapses as a function of previous activity. In the neocortex, direct synaptic interactions between areas play a central role in cognitive function, but the activity-dependent regulation of these long-range corticocortical connections and their impact on a postsynaptic target neuron is unclear. Here, we use an optogenetic strategy to study the connections between mouse primary somatosensory and motor cortex. We found that short-term facilitation was strong in both corticocortical synapses, resulting in far more sustained responses than local intracortical and thalamocortical connections. A major difference between pathways was that the synaptic strength and magnitude of facilitation were distinct for individual excitatory cells located across all cortical layers and specific subtypes of GABAergic neurons. Facilitation was dependent on the presynaptic calcium sensor synaptotagmin-7 and altered by several optogenetic approaches. Current-clamp recordings revealed that during repetitive activation, the short-term dynamics of corticocortical synapses enhanced the excitability of layer 2/3 pyramidal neurons, increasing the probabili",
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  "study_system": "Short-Term Facilitation of Long-Range Corticocortical Synapses Revealed by Selective Optical Stimulation.",
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  "claim_source_sentence": "Using selective optical stimulation of long-range corticocortical connections between mouse primary somatosensory and motor cortex, the authors found short-term facilitation was strong in both directions, resulting in far more sustained responses than is typical for local intracortical excitatory inputs.",
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Using selective optical stimulation of long-range corticocortical connections between mouse primary somatosensory and motor cortex, the authors found short-term facilitation was strong in both directions, resulting in far more sustained responses than is typical for local intracortical excitatory inputs.

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Short-term plasticity regulates the strength of central synapses as a function of previous activity. In the neocortex, direct synaptic interactions between areas play a central role in cognitive function, but the activity-dependent regulation of these long-range corticocortical connections and their impact on a postsynaptic target neuron is unclear. Here, we use an optogenetic strategy to study the connections between mouse primary somatosensory and motor cortex. We found that short-term facilitation was strong in both corticocortical synapses, resulting in far more sustained responses than local intracortical and thalamocortical connections. A major difference between pathways was that the synaptic strength and magnitude of facilitation were distinct for individual excitatory cells located across all cortical layers and specific subtypes of GABAergic neurons. Facilitation was dependent on the presynaptic calcium sensor synaptotagmin-7 and altered by several optogenetic approaches. Current-clamp recordings revealed that during repetitive activation, the short-term dynamics of corticocortical synapses enhanced the excitability of layer 2/3 pyramidal neurons, increasing the probabili