Version history

{
  "scope": "mouse Scn1a+/- Dravet syndrome model, longitudinal P16-P35+",
  "claim_text": "PV interneuron dysfunction in Dravet syndrome is dynamic: combined abnormalities of spike generation and axonal propagation drive early disease severity, while ongoing dysfunction of synaptic transmission contributes to chronic pathology even after spike generation normalizes.",
  "raw_fields": {
    "n": 0,
    "doi": "10.1016/j.celrep.2022.110580",
    "claim": "PV interneuron dysfunction in Dravet syndrome is dynamic: combined abnormalities of spike generation and axonal propagation drive early disease severity, while ongoing dysfunction of synaptic transmission contributes to chronic pathology even after spike generation normalizes.",
    "evidence": "Longitudinal assessment showed impaired spike generation in all Scn1a+/- mice at P16-21, with normalization by P35 in surviving mice. However, PV-IN synaptic transmission remains dysfunctional even at P35+.",
    "effect_size": "impaired spike generation at P16-21 normalizes by P35; synaptic transmission dysfunction persists",
    "text_access": "fulltext",
    "study_system": "mouse Scn1a+/- Dravet syndrome model, longitudinal P16-P35+",
    "replication_status": "replication_unknown",
    "claim_source_sentence": "These results demonstrate dynamic dysfunction in Dravet syndrome: combined abnormalities of PV-IN spike generation and propagation drives early disease severity, while ongoing dysfunction of synaptic transmission contributes to chronic pathology.",
    "replication_evidence_dois": [],
    "effect_size_source_sentence": "impaired spike generation in all Scn1a+/- mice at postnatal days (P) 16-21, whether deceased prior or surviving to P35, with normalization by P35 in surviving mice."
  },
  "section_id": "section_05_evidence_package",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_05_evidence_package.json",
  "effect_size": "impaired spike generation at P16-21 normalizes by P35; synaptic transmission dysfunction persists",
  "review_repo": "ComputationalReviewPV",
  "section_ref": "wiki_page:computationalreviewpv-05",
  "source_kind": "review_finding",
  "source_path": "evidence/section_05_evidence_package.json",
  "source_refs": [
    "paper:paper-d4a202dd1651"
  ],
  "source_span": "These results demonstrate dynamic dysfunction in Dravet syndrome: combined abnormalities of PV-IN spike generation and propagation drives early disease severity, while ongoing dysfunction of synaptic transmission contributes to chronic pathology.",
  "study_system": "mouse Scn1a+/- Dravet syndrome model, longitudinal P16-P35+",
  "evidence_refs": [
    {
      "ref": "paper:paper-d4a202dd1651"
    }
  ],
  "section_title": "Intrinsic Electrophysiology: The Fast-Spiking Phenotype and Its Variants",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "df9fc7e8d455b084152c9d713558dae0013cef21",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV"
  },
  "evidence_summary": "Longitudinal assessment showed impaired spike generation in all Scn1a+/- mice at P16-21, with normalization by P35 in surviving mice. However, PV-IN synaptic transmission remains dysfunctional even at P35+.",
  "review_bundle_ref": "analysis_bundle:ab-e6261c8263e7",
  "replication_status": "replication_unknown",
  "review_package_ref": "analysis_bundle:ab-e6261c8263e7",
  "source_artifact_ref": "wiki_page:computationalreviewpv-05",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_05_evidence_package.json",
  "commit_sha": "df9fc7e8d455b084152c9d713558dae0013cef21",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV"
}