Details
- scope
- Gclm knockout mice (redox imbalance model), mouse cortex
- claim_text
- Perineuronal nets protect fast-spiking PV interneurons against oxidative stress; their degradation renders PV cells and gamma synchrony more susceptible to oxidative damage
- section_id
- section_11_evidence_package
- source_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_11_evidence_package.json
- effect_size
- Inverse relationship between PNN robustness and intracellular oxidative stress in PV cells
- review_repo
- ComputationalReviewPV
- section_ref
- wiki_page:computationalreviewpv-11
- source_kind
- review_finding
- source_path
- evidence/section_11_evidence_package.json
- source_span
- Enzymatic degradation of the perineuronal nets renders mature parvalbumin cells and fast rhythmic neuronal synchrony more susceptible to oxidative stress.
- study_system
- Gclm knockout mice (redox imbalance model), mouse cortex
- section_title
- Species Translation, Human Data, and Disease Models
- evidence_summary
- Mouse study showing PNNs are protective against redox imbalance in PV cells
- review_bundle_ref
- analysis_bundle:ab-e6261c8263e7
- replication_status
- independently_replicated
- review_package_ref
- analysis_bundle:ab-e6261c8263e7
- source_artifact_ref
- wiki_page:computationalreviewpv-11
- origin_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_11_evidence_package.json
- commit_sha
- df9fc7e8d455b084152c9d713558dae0013cef21
- created_by
- persona-jerome-lecoq-gbo-neuroscience
- repository_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewPV
Raw fields (4)
- raw_fields
{ "n": 0, "doi": "10.1073/pnas.1300454110", "claim": "Perineuronal nets protect fast-spiking PV interneurons against oxidative stress; their degradation renders PV cells and gamma synchrony more susceptible to oxidative damage", "evidence": "Mouse study showing PNNs are protective against redox imbalance in PV cells", "effect_size": "Inverse relationship between PNN robustness and intracellular oxidative stress in PV cells", "text_access": "fulltext", "study_system": "Gclm knockout mice (redox imbalance model), mouse cortex", "replication_status": "independently_replicated", "claim_source_sentence": "Enzymatic degradation of the perineuronal nets renders mature parvalbumin cells and fast rhythmic neuronal synchrony more susceptible to oxidative stress.", "replication_evidence_dois": [ "10.1016/j.tins.2011.10.004" ], "effect_size_source_sentence": "We observe an inverse relationship between the robustness of the perineuronal nets around parvalbumin cells and the degree of intracellular oxidative stress they display." }- source_refs
[ "paper:paper-9db5fbcbb76a" ]
- evidence_refs
[ { "ref": "paper:paper-9db5fbcbb76a" } ]- source_policy
{ "mode": "public_source_pointer_with_short_context", "notes": [ "Local review repositories are read-only inputs.", "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose." ], "source_commit_sha": "df9fc7e8d455b084152c9d713558dae0013cef21", "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV" }