Version history

{
  "scope": "Tcf4+/tr mouse model of Pitt-Hopkins; bulk RNA-seq + IHC + electrophysiology",
  "claim_text": "Heterozygous TCF4 loss (Tcf4+/tr Pitt-Hopkins mouse model) selectively reduces PV+, VIP+, cortistatin+, and ChAT+ interneurons—but spares SST+ interneurons—causing cell-type-specific E/I imbalance onto PV+ and VIP+ INs and pyramidal neurons, evidence that a single transcription factor differentially regulates discrete molecularly-defined interneuron subclasses.",
  "raw_fields": {
    "n": null,
    "doi": "10.1038/s41380-023-02248-z",
    "claim": "Heterozygous TCF4 loss (Tcf4+/tr Pitt-Hopkins mouse model) selectively reduces PV+, VIP+, cortistatin+, and ChAT+ interneurons—but spares SST+ interneurons—causing cell-type-specific E/I imbalance onto PV+ and VIP+ INs and pyramidal neurons, evidence that a single transcription factor differentially regulates discrete molecularly-defined interneuron subclasses.",
    "title": null,
    "cite_key": "Chen2023b",
    "evidence": "Tcf4+/tr mouse model; CSEA + cellular deconvolution from bulk RNA-seq across 5 PTHS mouse models; IHC quantification with subtype markers; electrophysiology of E/I balance.",
    "effect_size": null,
    "text_access": "abstract_only",
    "study_system": "Tcf4+/tr mouse model of Pitt-Hopkins; bulk RNA-seq + IHC + electrophysiology",
    "target_section": "section_03",
    "_source_cluster": "cluster_01_molecular_taxonomy",
    "replication_status": "replication_unknown",
    "_source_cluster_index": 99,
    "claim_source_sentence": "In Tcf4+/tr mice, immunohistochemical (IHC) analysis of subtype-specific IN markers and reporter mice identified reductions in PV+, vasoactive intestinal peptide (VIP+), and cortistatin (CST+) expressing INs in the cortex and cholinergic (ChAT+) INs in the striatum, with the somatostatin (SST+) IN population being spared.",
    "replication_evidence_dois": [],
    "effect_size_source_sentence": null
  },
  "section_id": "section_11",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_11_evidence_package.json",
  "effect_size": null,
  "review_repo": "ComputationalReviewVIP",
  "section_ref": "wiki_page:computationalreviewvip-11-disease-translational",
  "source_kind": "review_finding",
  "source_path": "evidence/section_11_evidence_package.json",
  "source_refs": [
    "paper:paper-bcba2772b0e0"
  ],
  "source_span": "In Tcf4+/tr mice, immunohistochemical (IHC) analysis of subtype-specific IN markers and reporter mice identified reductions in PV+, vasoactive intestinal peptide (VIP+), and cortistatin (CST+) expressing INs in the cortex and cholinergic (ChAT+) INs in the striatum, with the somatostatin (SST+) IN population being spared.",
  "study_system": "Tcf4+/tr mouse model of Pitt-Hopkins; bulk RNA-seq + IHC + electrophysiology",
  "evidence_refs": [
    {
      "ref": "paper:paper-bcba2772b0e0"
    }
  ],
  "section_title": "Species Differences, Human Relevance, and Disease",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
  },
  "evidence_summary": "Tcf4+/tr mouse model; CSEA + cellular deconvolution from bulk RNA-seq across 5 PTHS mouse models; IHC quantification with subtype markers; electrophysiology of E/I balance.",
  "review_bundle_ref": "analysis_bundle:ab-2ce40c33e827",
  "replication_status": "replication_unknown",
  "review_package_ref": "analysis_bundle:ab-2ce40c33e827",
  "source_artifact_ref": "wiki_page:computationalreviewvip-11-disease-translational",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_11_evidence_package.json",
  "commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
}