Details
- scope
- mouse, dmPFC, single-unit recording + optogenetics
- claim_text
- Prefrontal PV interneuron phasic inhibition drives fear expression by disinhibiting projection neurons and resetting theta oscillations
- section_id
- section_08_evidence_package
- source_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_08_evidence_package.json
- effect_size
- causal relationship between PV inhibition and fear expression
- review_repo
- ComputationalReviewPV
- section_ref
- wiki_page:computationalreviewpv-08
- source_kind
- review_finding
- source_path
- evidence/section_08_evidence_package.json
- source_span
- fear expression is causally related to the phasic inhibition of prefrontal parvalbumin interneurons (PVINs)
- study_system
- mouse, dmPFC, single-unit recording + optogenetics
- section_title
- In Vivo Dynamics and Behavioural Correlates
- evidence_summary
- Inhibition of PVIN activity disinhibits prefrontal projection neurons and synchronizes their firing by resetting local theta oscillations, leading to fear expression
- review_bundle_ref
- analysis_bundle:ab-e6261c8263e7
- replication_status
- independently_replicated
- review_package_ref
- analysis_bundle:ab-e6261c8263e7
- source_artifact_ref
- wiki_page:computationalreviewpv-08
- origin_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_08_evidence_package.json
- commit_sha
- df9fc7e8d455b084152c9d713558dae0013cef21
- created_by
- persona-jerome-lecoq-gbo-neuroscience
- repository_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewPV
Raw fields (4)
- raw_fields
{ "n": 0, "doi": "10.1038/nature12755", "claim": "Prefrontal PV interneuron phasic inhibition drives fear expression by disinhibiting projection neurons and resetting theta oscillations", "evidence": "Inhibition of PVIN activity disinhibits prefrontal projection neurons and synchronizes their firing by resetting local theta oscillations, leading to fear expression", "effect_size": "causal relationship between PV inhibition and fear expression", "text_access": "abstract_only", "study_system": "mouse, dmPFC, single-unit recording + optogenetics", "replication_status": "independently_replicated", "claim_source_sentence": "fear expression is causally related to the phasic inhibition of prefrontal parvalbumin interneurons (PVINs)", "replication_evidence_dois": [ "10.1038/s41593-018-0073-9", "10.1523/JNEUROSCI.1442-22.2023" ], "effect_size_source_sentence": "Inhibition of PVIN activity disinhibits prefrontal projection neurons and synchronizes their firing by resetting local theta oscillations, leading to fear expression" }- source_refs
[ "paper:paper-dc070781ea08" ]
- evidence_refs
[ { "ref": "paper:paper-dc070781ea08" } ]- source_policy
{ "mode": "public_source_pointer_with_short_context", "notes": [ "Local review repositories are read-only inputs.", "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose." ], "source_commit_sha": "df9fc7e8d455b084152c9d713558dae0013cef21", "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV" }