Version history

{
  "scope": "mouse hippocampus",
  "claim_text": "We expressed each of our 4 GEVIs in vasoactive intestinal peptide-expressing (VIP + ) interneurons in primary visual cortex (V1), in which they successfully reported single action potentials ( Fig.",
  "raw_fields": {
    "n": 13,
    "doi": "10.1126/science.abm8797",
    "year": "2022",
    "claim": "We expressed each of our 4 GEVIs in vasoactive intestinal peptide-expressing (VIP + ) interneurons in primary visual cortex (V1), in which they successfully reported single action potentials ( Fig.",
    "title": null,
    "journal": "Science (New York, N.Y.)",
    "cite_key": "Kannan2022",
    "evidence": "Dual-polarity voltage imaging of the concurrent dynamics of multiple neuron types",
    "effect_size": "120 mV",
    "text_access": "fulltext",
    "study_system": "mouse hippocampus",
    "_source_cluster": "cluster_06_disinhibition_circuit",
    "replication_status": "replicated",
    "_source_cluster_index": 47,
    "claim_source_sentence": "We expressed each of our 4 GEVIs in vasoactive intestinal peptide-expressing (VIP + ) interneurons in primary visual cortex (V1), in which they successfully reported single action potentials ( Fig.",
    "replication_evidence_dois": [
      "10.1016/j.cell.2014.01.050",
      "10.7554/elife.14985",
      "10.1016/j.neuron.2018.03.037"
    ],
    "effect_size_source_sentence": "Ace-mNeon N81S G229Y and VARNAM Δ228W Δ229R G231I (henceforth, Ace-mNeon2 and VARNAM2, respectively) exhibited significantly improved fluorescence responses to depolarizing voltages compared to their predecessors in patch-clamp recordings from transfected cells ( ΔF / F for 120 mV step were (mean ± S.E.M.): −31.3 ± 0.7% for Ace-mNeon2 (n=13 cells) versus −13.9 ± 0.6% for Ace-mNeon (n=11 cells), P <0.0001, Mann-Whitney test; −22.9 ± 0.7% for VARNAM2 (n=13 cells) versus −14.1 ± 0.5% for VARNAM (n=8 cells), P <0.0001, Mann-Whitney test) ( Fig."
  },
  "section_id": "section_01",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_01_evidence_package.json",
  "effect_size": "120 mV",
  "review_repo": "ComputationalReviewVIP",
  "section_ref": "wiki_page:computationalreviewvip-01-introduction",
  "source_kind": "review_finding",
  "source_path": "evidence/section_01_evidence_package.json",
  "source_refs": [
    "paper:paper-5e76016e87f0"
  ],
  "source_span": "We expressed each of our 4 GEVIs in vasoactive intestinal peptide-expressing (VIP + ) interneurons in primary visual cortex (V1), in which they successfully reported single action potentials ( Fig.",
  "study_system": "mouse hippocampus",
  "evidence_refs": [
    {
      "ref": "paper:paper-5e76016e87f0"
    }
  ],
  "section_title": "Introduction",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
  },
  "evidence_summary": "Dual-polarity voltage imaging of the concurrent dynamics of multiple neuron types",
  "review_bundle_ref": "analysis_bundle:ab-2ce40c33e827",
  "replication_status": "replicated",
  "review_package_ref": "analysis_bundle:ab-2ce40c33e827",
  "source_artifact_ref": "wiki_page:computationalreviewvip-01-introduction",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_01_evidence_package.json",
  "commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
}