Version history

{
  "scope": "mouse (slice electrophysiology)",
  "claim_text": "Cowley et al. show that leptin directly excites POMC neurons and inhibits AGRP neurons in the arcuate nucleus, providing the cellular substrate for melanocortin-mediated leptin anorexigenic action.",
  "raw_fields": {
    "n": null,
    "doi": "10.1038/35078085",
    "claim": "Cowley et al. show that leptin directly excites POMC neurons and inhibits AGRP neurons in the arcuate nucleus, providing the cellular substrate for melanocortin-mediated leptin anorexigenic action.",
    "cite_key": "Cowley2001",
    "evidence": "abstract_only",
    "effect_size": null,
    "text_access": "abstract",
    "study_system": "mouse (slice electrophysiology)",
    "source_cluster_id": "cluster_08",
    "replication_status": "unreplicated",
    "claim_source_sentence": "The administration of leptin to leptin-deficient humans, and the analogous Lepob/Lepob mice, effectively reduces hyperphagia and obesity.",
    "replication_evidence_dois": [],
    "effect_size_source_sentence": null
  },
  "section_id": "section_09",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops/blob/0632aae8abc141909207fe91f6349b9e36489c3b/evidence/section_09_evidence_package.json",
  "effect_size": null,
  "review_repo": "ComputationalReviewLoops",
  "section_ref": "wiki_page:computationalreviewloops-09",
  "source_kind": "review_finding",
  "source_path": "evidence/section_09_evidence_package.json",
  "source_refs": [
    "paper:f56751ff-25b8-46a4-abbc-7ef6e68497ac"
  ],
  "source_span": "The administration of leptin to leptin-deficient humans, and the analogous Lepob/Lepob mice, effectively reduces hyperphagia and obesity.",
  "study_system": "mouse (slice electrophysiology)",
  "evidence_refs": [
    {
      "ref": "paper:f56751ff-25b8-46a4-abbc-7ef6e68497ac"
    }
  ],
  "section_title": "The Hypothalamic Extension: Loops for Motivated Behavior",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "0632aae8abc141909207fe91f6349b9e36489c3b",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops"
  },
  "evidence_summary": "abstract_only",
  "review_bundle_ref": "analysis_bundle:ab-d49e54403ef9",
  "replication_status": "unreplicated",
  "review_package_ref": "analysis_bundle:ab-d49e54403ef9",
  "source_artifact_ref": "wiki_page:computationalreviewloops-09",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops/blob/0632aae8abc141909207fe91f6349b9e36489c3b/evidence/section_09_evidence_package.json",
  "commit_sha": "0632aae8abc141909207fe91f6349b9e36489c3b",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops"
}