- claim_text
In mouse layer-4 barrel cortex, photoinhibition of fast-spiking interneurons reduces their activity and increases L4 excitatory firing — opposite to the 'paradoxical effect' expected of inhibition-stabilized strongly-coupled networks; a network model constrained by in vitro connectivity reproduces this by feedforward inhibition combined with intracortical circuitry suppressing baseline and movement-related activity.
- raw_fields
{
"n": 0,
"doi": "10.1371/journal.pcbi.1005576",
"claim": "In mouse layer-4 barrel cortex, photoinhibition of fast-spiking interneurons reduces their activity and increases L4 excitatory firing — opposite to the 'paradoxical effect' expected of inhibition-stabilized strongly-coupled networks; a network model constrained by in vitro connectivity reproduces this by feedforward inhibition combined with intracortical circuitry suppressing baseline and movement-related activity.",
"cite_key": "Gutnisky2017",
"evidence": "The model explores the various synaptic conductance strengths for which L4 FS neurons actively suppress baseline and movement-related activity in layer 4 excitatory neurons. Feedforward inhibition, in concert with recurrent intracortical circuitry, produces tactile suppression.",
"effect_size": "",
"text_access": "fulltext",
"study_system": "mouse layer 4 barrel cortex; in vivo halorhodopsin inactivation of fast-spiking interneurons + biophysical model constrained by paired recordings",
"argument_role": "supporting",
"replication_status": "single_lab",
"claim_source_sentence": "Stimulation of halorhodopsin in FS interneurons causes a reduction in FS neuron activity and an increase in L4 excitatory neuron activity. This decrease of activity of L4 FS neurons contradicts the 'paradoxical effect' predicted in networks stabilized by inhibition and in strongly-coupled networks.",
"source_provenance_status": "ok",
"replication_evidence_dois": [],
"effect_size_source_sentence": null
}- source_refs
[
"paper:02525fad-059b-4ffc-ba1c-e5445baddd4d"
]
- source_span
Stimulation of halorhodopsin in FS interneurons causes a reduction in FS neuron activity and an increase in L4 excitatory neuron activity. This decrease of activity of L4 FS neurons contradicts the 'paradoxical effect' predicted in networks stabilized by inhibition and in strongly-coupled networks.
- evidence_refs
[
{
"ref": "paper:02525fad-059b-4ffc-ba1c-e5445baddd4d"
}
]- source_policy
{
"mode": "public_source_pointer_with_short_context",
"notes": [
"Local review repositories are read-only inputs.",
"SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
],
"source_commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
"source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
}- evidence_summary
The model explores the various synaptic conductance strengths for which L4 FS neurons actively suppress baseline and movement-related activity in layer 4 excitatory neurons. Feedforward inhibition, in concert with recurrent intracortical circuitry, produces tactile suppression.