Version history

{
  "scope": "thalamocortical system (theoretical review)",
  "claim_text": "Matrix thalamic neurons (with deep-layer cortical interactions) regulate global state and perceptual thresholds, while core thalamic neurons maintain perceptual content; coherent activity in thalamocortical loops underlies experiential continuity.",
  "raw_fields": {
    "n": 0,
    "doi": "10.1016/j.neuron.2024.04.019",
    "claim": "Matrix thalamic neurons (with deep-layer cortical interactions) regulate global state and perceptual thresholds, while core thalamic neurons maintain perceptual content; coherent activity in thalamocortical loops underlies experiential continuity.",
    "cite_key": "Whyte2024",
    "evidence": "Theoretical synthesis of thalamic-cellular and systems data on conscious state vs content.",
    "effect_size": "es within a narrow band (0.75–1.5Hz) 56 .",
    "text_access": "fulltext",
    "study_system": "thalamocortical system (theoretical review)",
    "source_cluster_id": "cluster_05",
    "replication_status": "independently_replicated",
    "claim_source_sentence": "Optogenetic stimulation experiments in vivo demonstrate that ttL5Bs, more-so than L2/3 pyramidal neurons, generate cortical slow-waves (1Hz) 84 , 85 ; for reviews, see 51 , 86 . ttL5Bs also uniquely synchronize in up-down states across cortex under general anesthesia relative to neurons in other cortical layers 87 .",
    "replication_evidence_dois": [
      "10.1016/j.celrep.2023.112844",
      "10.1016/s0166-2236(00)01922-6"
    ],
    "effect_size_source_sentence": "In vivo thalamic manipulation experiments have further reinforced the role of the thalamus in electrophysiological signatures of brain states: thalamic inhibition in freely moving rats has been shown to alter both sleep spindles and slow cortical waves, while optogenetic activation entrains slow-wave frequencies within a narrow band (0.75–1.5Hz) 56 ."
  },
  "section_id": "section_06",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops/blob/0632aae8abc141909207fe91f6349b9e36489c3b/evidence/section_06_evidence_package.json",
  "effect_size": "es within a narrow band (0.75–1.5Hz) 56 .",
  "review_repo": "ComputationalReviewLoops",
  "section_ref": "wiki_page:computationalreviewloops-06",
  "source_kind": "review_finding",
  "source_path": "evidence/section_06_evidence_package.json",
  "source_refs": [
    "paper:paper-bf1ace3532d4"
  ],
  "source_span": "Optogenetic stimulation experiments in vivo demonstrate that ttL5Bs, more-so than L2/3 pyramidal neurons, generate cortical slow-waves (1Hz) 84 , 85 ; for reviews, see 51 , 86 . ttL5Bs also uniquely synchronize in up-down states across cortex under general anesthesia relative to neurons in other cortical layers 87 .",
  "study_system": "thalamocortical system (theoretical review)",
  "evidence_refs": [
    {
      "ref": "paper:paper-bf1ace3532d4"
    }
  ],
  "section_title": "Thalamic Feedback: Closing the Loop",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "0632aae8abc141909207fe91f6349b9e36489c3b",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops"
  },
  "evidence_summary": "Theoretical synthesis of thalamic-cellular and systems data on conscious state vs content.",
  "review_bundle_ref": "analysis_bundle:ab-d49e54403ef9",
  "replication_status": "independently_replicated",
  "review_package_ref": "analysis_bundle:ab-d49e54403ef9",
  "source_artifact_ref": "wiki_page:computationalreviewloops-06",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops/blob/0632aae8abc141909207fe91f6349b9e36489c3b/evidence/section_06_evidence_package.json",
  "commit_sha": "0632aae8abc141909207fe91f6349b9e36489c3b",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops"
}