Paired recordings between L2/3 VIP and L4 SST cells in mouse S1 vs V1 reveal th…

Paired recordings between L2/3 VIP and L4 SST cells in mouse S1 vs V1 reveal that L4 SST cells are non-Martinotti (nMC) in S1 but Martinotti-like (MC) in V1; ~40–45% of SST cells receive VIP input in both areas with similar unitary properties but distinct short-term plasticity (some facilitating, some stable, a fraction of VIP→nMC depressing).

{
  "n": null,
  "doi": "10.1523/jneurosci.0949-24.2025",
  "claim": "Paired recordings between L2/3 VIP and L4 SST cells in mouse S1 vs V1 reveal that L4 SST cells are non-Martinotti (nMC) in S1 but Martinotti-like (MC) in V1; ~40–45% of SST cells receive VIP input in both areas with similar unitary properties but distinct short-term plasticity (some facilitating, some stable, a fraction of VIP→nMC depressing).",
  "title": null,
  "cite_key": "Rachel2025",
  "evidence": "Paired whole-cell patch-clamp + morphological reconstructions of L2/3 VIP onto L4 SST cells in S1 and V1.",
  "effect_size": "~40–45% Pcon for VIP→SST in both S1 and V1; differential STP between VIP→nMC and VIP→MC",
  "text_access": "abstract_only",
  "study_system": "mouse S1 and V1 slice paired recordings",
  "_source_cluster": "cluster_05_synaptic_connectivity",
  "replication_status": "replicated",
  "_source_cluster_index": 24,
  "claim_source_sentence": "Approximately 40-45% of tested SST cells were inhibited by VIP cells in both cortices.",
  "replication_evidence_dois": [
    "10.1038/nn.3446",
    "10.1038/ncomms13664"
  ],
  "effect_size_source_sentence": "Approximately 40-45% of tested SST cells were inhibited by VIP cells in both cortices."
}

[
  "paper:paper-55e1027b727c"
]

[
  {
    "ref": "paper:paper-55e1027b727c"
  }
]

{
  "mode": "public_source_pointer_with_short_context",
  "notes": [
    "Local review repositories are read-only inputs.",
    "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
  ],
  "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
  "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
}