Version history

{
  "scope": "mouse, cortico-subthalamo-nigral (hyperdirect) pathway in basal ganglia",
  "claim_text": "Selective elimination of the cortico-subthalamic hyperdirect pathway diminishes cortically evoked early excitation in the SNr and induces motor hyperactivity, supporting the role of this pathway in resetting or suppressing ongoing movements.",
  "raw_fields": {
    "n": null,
    "doi": "10.1523/jneurosci.1330-20.2021",
    "claim": "Selective elimination of the cortico-subthalamic hyperdirect pathway diminishes cortically evoked early excitation in the SNr and induces motor hyperactivity, supporting the role of this pathway in resetting or suppressing ongoing movements.",
    "cite_key": "Koketsu2021",
    "evidence": "A photodynamic technique was used to selectively eliminate the cortico-STN projection in male mice, followed by observation of neuronal activity in the SNr and motor behaviors in awake conditions.",
    "effect_size": null,
    "text_access": "abstract_only",
    "study_system": "mouse, cortico-subthalamo-nigral (hyperdirect) pathway in basal ganglia",
    "source_cluster_id": "cluster_01",
    "replication_status": "novel",
    "claim_source_sentence": "After cortico-STN elimination, cortically evoked early excitation in the SNr was diminished, while the cortically evoked inhibition and late excitation, which are delivered through the direct and indirect pathways, respectively, were unchanged. In addition, locomotor activity was significantly increased after bilateral cortico-STN elimination, and apomorphine-induced ipsilateral rotations were observed after unilateral cortico-STN elimination, suggesting that cortical activity was increased.",
    "replication_evidence_dois": [],
    "effect_size_source_sentence": null
  },
  "section_id": "section_01",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops/blob/0632aae8abc141909207fe91f6349b9e36489c3b/evidence/section_01_evidence_package.json",
  "effect_size": null,
  "review_repo": "ComputationalReviewLoops",
  "section_ref": "wiki_page:computationalreviewloops-01",
  "source_kind": "review_finding",
  "source_path": "evidence/section_01_evidence_package.json",
  "source_refs": [
    "paper:paper-68824b03d404"
  ],
  "source_span": "After cortico-STN elimination, cortically evoked early excitation in the SNr was diminished, while the cortically evoked inhibition and late excitation, which are delivered through the direct and indirect pathways, respectively, were unchanged. In addition, locomotor activity was significantly increased after bilateral cortico-STN elimination, and apomorphine-induced ipsilateral rotations were observed after unilate...",
  "study_system": "mouse, cortico-subthalamo-nigral (hyperdirect) pathway in basal ganglia",
  "evidence_refs": [
    {
      "ref": "paper:paper-68824b03d404"
    }
  ],
  "section_title": "Introduction: Swanson's Loop Hypothesis and Its Intellectual Lineage",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "0632aae8abc141909207fe91f6349b9e36489c3b",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops"
  },
  "evidence_summary": "A photodynamic technique was used to selectively eliminate the cortico-STN projection in male mice, followed by observation of neuronal activity in the SNr and motor behaviors in awake conditions.",
  "review_bundle_ref": "analysis_bundle:ab-d49e54403ef9",
  "replication_status": "novel",
  "review_package_ref": "analysis_bundle:ab-d49e54403ef9",
  "source_artifact_ref": "wiki_page:computationalreviewloops-01",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops/blob/0632aae8abc141909207fe91f6349b9e36489c3b/evidence/section_01_evidence_package.json",
  "commit_sha": "0632aae8abc141909207fe91f6349b9e36489c3b",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops"
}