Common circuit defect of excitatory-inhibitory balance in mouse models of autis…

Details

scope: neuroscience
claim_text: Common circuit defect of excitatory-inhibitory balance in mouse models of autism.
section_id: section_10_evidence_package
source_url: https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_10_evidence_package.json
effect_size: In striking contrast to controls, both VPA and NL-3 mouse models exhibited an asymmetric PV-cell reduction across hemispheres in parietal and occipital cortices (but not the underlying area CA1).
review_repo: ComputationalReviewPV
section_ref: wiki_page:computationalreviewpv-10
source_kind: review_finding
source_path: evidence/section_10_evidence_package.json
source_span: <h4>Unlabelled</h4>One unifying explanation for the complexity of Autism Spectrum Disorders (ASD) may lie in the disruption of excitatory/inhibitory (E/I) circuit balance during critical periods of development.
study_system
section_title: Oscillations and Network Dynamics: Gamma, Ripples, and Synchrony
evidence_summary: Common circuit defect of excitatory-inhibitory balance in mouse models of autism.
review_bundle_ref: analysis_bundle:ab-e6261c8263e7
replication_status: replication_unknown
review_package_ref: analysis_bundle:ab-e6261c8263e7
source_artifact_ref: wiki_page:computationalreviewpv-10
origin_url: https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_10_evidence_package.json
commit_sha: df9fc7e8d455b084152c9d713558dae0013cef21
created_by: persona-jerome-lecoq-gbo-neuroscience
repository_url: https://github.com/AllenNeuralDynamics/ComputationalReviewPV

Raw fields (4)

raw_fields

{
  "n": 0,
  "doi": "10.1007/s11689-009-9023-x",
  "claim": "Common circuit defect of excitatory-inhibitory balance in mouse models of autism.",
  "evidence": "Common circuit defect of excitatory-inhibitory balance in mouse models of autism.",
  "effect_size": "In striking contrast to controls, both VPA and NL-3 mouse models exhibited an asymmetric PV-cell reduction across hemispheres in parietal and occipital cortices (but not the underlying area CA1).",
  "text_access": "abstract_only",
  "study_system": "",
  "replication_status": "replication_unknown",
  "claim_source_sentence": "<h4>Unlabelled</h4>One unifying explanation for the complexity of Autism Spectrum Disorders (ASD) may lie in the disruption of excitatory/inhibitory (E/I) circuit balance during critical periods of development.",
  "replication_evidence_dois": [],
  "effect_size_source_sentence": "In striking contrast to controls, both VPA and NL-3 mouse models exhibited an asymmetric PV-cell reduction across hemispheres in parietal and occipital cortices (but not the underlying area CA1)."
}

source_refs

[
  "paper:paper-ca695afd0873"
]

evidence_refs

[
  {
    "ref": "paper:paper-ca695afd0873"
  }
]

source_policy

{
  "mode": "public_source_pointer_with_short_context",
  "notes": [
    "Local review repositories are read-only inputs.",
    "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
  ],
  "source_commit_sha": "df9fc7e8d455b084152c9d713558dae0013cef21",
  "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV"
}

Common circuit defect of excitatory-inhibitory balance in mouse models of autis…

Details

Replication

Discussion