- claim_text
The jGCaMP7 family of green-fluorescent calcium indicators provides distinct variants optimized for single-spike detection (jGCaMP7s,f), neurite/neuropil imaging (jGCaMP7b), and wide-field population imaging (jGCaMP7c) — the indicator landscape that bounds what 'large-scale calcium recording' in mouse cortex actually measures.
- raw_fields
{
"n": 0,
"doi": "10.1038/s41592-019-0435-6",
"claim": "The jGCaMP7 family of green-fluorescent calcium indicators provides distinct variants optimized for single-spike detection (jGCaMP7s,f), neurite/neuropil imaging (jGCaMP7b), and wide-field population imaging (jGCaMP7c) — the indicator landscape that bounds what 'large-scale calcium recording' in mouse cortex actually measures.",
"cite_key": "Dana2019",
"evidence": "Structure-guided + neuron-based screening; four jGCaMP7 variants benchmarked across imaging modalities.",
"effect_size": "4 specialized variants for distinct in vivo modes (spikes/neurites/population)",
"text_access": "abstract_only",
"study_system": "GECI engineering benchmark (cultured + in vivo, mouse cortex)",
"argument_role": "supporting",
"replication_status": "indicator-paper",
"claim_source_sentence": "The resulting jGCaMP7 sensors provide improved detection of individual spikes (jGCaMP7s,f), imaging in neurites and neuropil (jGCaMP7b), and may allow tracking larger populations of neurons using two-photon (jGCaMP7s,f) or wide-field (jGCaMP7c) imaging.",
"source_provenance_status": "non_substring_match",
"replication_evidence_dois": [],
"effect_size_source_sentence": "The resulting jGCaMP7 sensors provide improved detection of individual spikes (jGCaMP7s,f), imaging in neurites and neuropil (jGCaMP7b)"
}- source_refs
[
"paper:f9da5cad-8241-41b3-8528-a8e55cc5f0e1"
]
- source_span
The resulting jGCaMP7 sensors provide improved detection of individual spikes (jGCaMP7s,f), imaging in neurites and neuropil (jGCaMP7b), and may allow tracking larger populations of neurons using two-photon (jGCaMP7s,f) or wide-field (jGCaMP7c) imaging.
- evidence_refs
[
{
"ref": "paper:f9da5cad-8241-41b3-8528-a8e55cc5f0e1"
}
]- section_title
15. Methodological limits and emerging tools — what current mouse-cortex tools cannot yet measure about E→E recurrence (subthreshold network activity, fast plasticity in vivo, millimetre-scale dynamic connectomes), and what is on the near horizon
- source_policy
{
"mode": "public_source_pointer_with_short_context",
"notes": [
"Local review repositories are read-only inputs.",
"SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
],
"source_commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
"source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
}