Schizophrenia is associated with multiple pre- and post-synaptic abnormalities…

Details

scope: human postmortem DLPFC, schizophrenia
claim_text: Schizophrenia is associated with multiple pre- and post-synaptic abnormalities in parvalbumin basket cells that weaken their inhibitory control of pyramidal cells
section_id: section_11_evidence_package
source_url: https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_11_evidence_package.json
effect_size: Lower GAD67 mRNA levels in ~50% of PV+ neurons in DLPFC layer 3
review_repo: ComputationalReviewPV
section_ref: wiki_page:computationalreviewpv-11
source_kind: review_finding
source_path: evidence/section_11_evidence_package.json
source_span: Recent findings indicate that schizophrenia is associated with multiple pre- and post-synaptic abnormalities in PVBCs, each of which weakens their inhibitory control of pyramidal cells.
study_system: human postmortem DLPFC, schizophrenia
section_title: Species Translation, Human Data, and Disease Models
evidence_summary: Fulltext review of postmortem and molecular evidence for PVBC dysfunction in schizophrenia DLPFC
review_bundle_ref: analysis_bundle:ab-e6261c8263e7
replication_status: independently_replicated
review_package_ref: analysis_bundle:ab-e6261c8263e7
source_artifact_ref: wiki_page:computationalreviewpv-11
origin_url: https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_11_evidence_package.json
commit_sha: df9fc7e8d455b084152c9d713558dae0013cef21
created_by: persona-jerome-lecoq-gbo-neuroscience
repository_url: https://github.com/AllenNeuralDynamics/ComputationalReviewPV

Raw fields (4)

raw_fields

{
  "n": 0,
  "doi": "10.1016/j.tins.2011.10.004",
  "claim": "Schizophrenia is associated with multiple pre- and post-synaptic abnormalities in parvalbumin basket cells that weaken their inhibitory control of pyramidal cells",
  "evidence": "Fulltext review of postmortem and molecular evidence for PVBC dysfunction in schizophrenia DLPFC",
  "effect_size": "Lower GAD67 mRNA levels in ~50% of PV+ neurons in DLPFC layer 3",
  "text_access": "fulltext",
  "study_system": "human postmortem DLPFC, schizophrenia",
  "replication_status": "independently_replicated",
  "claim_source_sentence": "Recent findings indicate that schizophrenia is associated with multiple pre- and post-synaptic abnormalities in PVBCs, each of which weakens their inhibitory control of pyramidal cells.",
  "replication_evidence_dois": [
    "10.1093/schbul/sbn070",
    "10.1016/j.biopsych.2015.03.010"
  ],
  "effect_size_source_sentence": "In the DLPFC, GAD67 mRNA levels are lower in schizophrenia, and this deficit appears to be present in ~50% of PV neurons."
}

source_refs

[
  "paper:paper-6d36973b50ab"
]

evidence_refs

[
  {
    "ref": "paper:paper-6d36973b50ab"
  }
]

source_policy

{
  "mode": "public_source_pointer_with_short_context",
  "notes": [
    "Local review repositories are read-only inputs.",
    "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
  ],
  "source_commit_sha": "df9fc7e8d455b084152c9d713558dae0013cef21",
  "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV"
}

Schizophrenia is associated with multiple pre- and post-synaptic abnormalities…

Details

Replication

Discussion