Version history

{
  "scope": "human (postmortem/iPSC/organoid)",
  "claim_text": "Impaired action potential initiation in GABAergic interneurons causes hyperexcitable networks in an epileptic mouse model carrying a human Na(V)1.1 mutation — Mutations in SCN1A and other ion channel genes can cause different epileptic phenotypes, but the precise mechanisms underlying the development of hyperexcitable",
  "raw_fields": {
    "n": 0,
    "doi": "10.1523/jneurosci.0721-14.2014",
    "claim": "Impaired action potential initiation in GABAergic interneurons causes hyperexcitable networks in an epileptic mouse model carrying a human Na(V)1.1 mutation — Mutations in SCN1A and other ion channel genes can cause different epileptic phenotypes, but the precise mechanisms underlying the development of hyperexcitable",
    "title": null,
    "cite_key": "Hedrich2014",
    "evidence": "Reported in The Journal of neuroscience : the official journal of the Society for Neuroscience (2014); from Body of abstract.",
    "effect_size": "1",
    "text_access": "abstract_only",
    "study_system": "human (postmortem/iPSC/organoid)",
    "_source_cluster": "cluster_05_synaptic_connectivity",
    "replication_status": "replication_unknown",
    "_source_cluster_index": 364,
    "claim_source_sentence": "Mutations in SCN1A and other ion channel genes can cause different epileptic phenotypes, but the precise mechanisms underlying the development of hyperexcitable networks are largely unknown.",
    "replication_evidence_dois": [],
    "effect_size_source_sentence": "Here, we present a multisystem analysis of an SCN1A mouse model carrying the NaV1.1-R1648H mutation, which causes febrile seizures and epilepsy in humans."
  },
  "section_id": "section_06",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_06_evidence_package.json",
  "effect_size": "1",
  "review_repo": "ComputationalReviewVIP",
  "section_ref": "wiki_page:computationalreviewvip-06-synaptic-properties",
  "source_kind": "review_finding",
  "source_path": "evidence/section_06_evidence_package.json",
  "source_refs": [
    "paper:paper-7a06f96aaed3"
  ],
  "source_span": "Mutations in SCN1A and other ion channel genes can cause different epileptic phenotypes, but the precise mechanisms underlying the development of hyperexcitable networks are largely unknown.",
  "study_system": "human (postmortem/iPSC/organoid)",
  "evidence_refs": [
    {
      "ref": "paper:paper-7a06f96aaed3"
    }
  ],
  "section_title": "Synaptic Properties and Connectivity",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
  },
  "evidence_summary": "Reported in The Journal of neuroscience : the official journal of the Society for Neuroscience (2014); from Body of abstract.",
  "review_bundle_ref": "analysis_bundle:ab-2ce40c33e827",
  "replication_status": "replication_unknown",
  "review_package_ref": "analysis_bundle:ab-2ce40c33e827",
  "source_artifact_ref": "wiki_page:computationalreviewvip-06-synaptic-properties",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_06_evidence_package.json",
  "commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
}