ErbB4 plays functionally distinct roles in PV interneurons versus dopaminergic…

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scope: mouse, ErbB4 conditional KO in TH+ vs PV+ cells
claim_text: ErbB4 plays functionally distinct roles in PV interneurons versus dopaminergic neurons: in DA neurons it regulates extracellular DA levels, while in PV cells it regulates excitatory input.
section_id: section_02_evidence_package
source_url: https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_02_evidence_package.json
effect_size: cell-type-specific ErbB4 functions: DA regulation in TH+ neurons, not in PV+ cells
review_repo: ComputationalReviewPV
section_ref: wiki_page:computationalreviewpv-02
source_kind: review_finding
source_path: evidence/section_02_evidence_package.json
source_span: Mice lacking ErbB4 in tyrosine hydroxylase-positive (TH+) neurons, but not in PV+ GABAergic interneurons, exhibit different regional imbalances of basal DA levels.
study_system: mouse, ErbB4 conditional KO in TH+ vs PV+ cells
section_title: Molecular Identity and Transcriptomic Taxonomy
evidence_summary
review_bundle_ref: analysis_bundle:ab-e6261c8263e7
replication_status: replication_unknown
review_package_ref: analysis_bundle:ab-e6261c8263e7
source_artifact_ref: wiki_page:computationalreviewpv-02
origin_url: https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_02_evidence_package.json
commit_sha: df9fc7e8d455b084152c9d713558dae0013cef21
created_by: persona-jerome-lecoq-gbo-neuroscience
repository_url: https://github.com/AllenNeuralDynamics/ComputationalReviewPV

Raw fields (4)

raw_fields

{
  "n": 0,
  "doi": "10.1038/mp.2017.132",
  "claim": "ErbB4 plays functionally distinct roles in PV interneurons versus dopaminergic neurons: in DA neurons it regulates extracellular DA levels, while in PV cells it regulates excitatory input.",
  "evidence": "",
  "effect_size": "cell-type-specific ErbB4 functions: DA regulation in TH+ neurons, not in PV+ cells",
  "text_access": "abstract_only",
  "study_system": "mouse, ErbB4 conditional KO in TH+ vs PV+ cells",
  "replication_status": "replication_unknown",
  "claim_source_sentence": "Mice lacking ErbB4 in tyrosine hydroxylase-positive (TH+) neurons, but not in PV+ GABAergic interneurons, exhibit different regional imbalances of basal DA levels.",
  "replication_evidence_dois": [],
  "effect_size_source_sentence": "Mice lacking ErbB4 in tyrosine hydroxylase-positive (TH+) neurons, but not in PV+ GABAergic interneurons, exhibit different regional imbalances of basal DA levels"
}

source_refs

[
  "paper:paper-39d2f687db2e"
]

evidence_refs

[
  {
    "ref": "paper:paper-39d2f687db2e"
  }
]

source_policy

{
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  "notes": [
    "Local review repositories are read-only inputs.",
    "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
  ],
  "source_commit_sha": "df9fc7e8d455b084152c9d713558dae0013cef21",
  "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV"
}

ErbB4 plays functionally distinct roles in PV interneurons versus dopaminergic…

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