Version history

{
  "scope": "human + rodent neocortex; AIS structural/functional comparison",
  "claim_text": "Fast-spiking interneurons in human neocortex possess axon-initial-segment (AIS) adaptations distinct from rodent FS-INs, including altered AIS length and Na+/K+ channel composition, contributing to species-specific high-frequency firing properties—evidence that the canonical 'PV-FS-IN' molecular class has structural divergence between mouse and human despite transcriptomic homology.",
  "raw_fields": {
    "n": null,
    "doi": "10.1371/journal.pbio.3003549",
    "claim": "Fast-spiking interneurons in human neocortex possess axon-initial-segment (AIS) adaptations distinct from rodent FS-INs, including altered AIS length and Na+/K+ channel composition, contributing to species-specific high-frequency firing properties—evidence that the canonical 'PV-FS-IN' molecular class has structural divergence between mouse and human despite transcriptomic homology.",
    "title": null,
    "cite_key": "Bakos2025",
    "evidence": "Human neurosurgical specimens + IHC of AIS markers + correlated electrophysiology; comparison to rodent FS-INs.",
    "effect_size": null,
    "text_access": "abstract_only",
    "study_system": "human + rodent neocortex; AIS structural/functional comparison",
    "target_section": "section_11",
    "_source_cluster": "cluster_01_molecular_taxonomy",
    "replication_status": "replication_unknown",
    "_source_cluster_index": 125,
    "claim_source_sentence": "Adaptations of the axon initial segment in fast-spiking interneurons of the human neocortex.",
    "replication_evidence_dois": [],
    "effect_size_source_sentence": null
  },
  "section_id": "section_01",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_01_evidence_package.json",
  "effect_size": null,
  "review_repo": "ComputationalReviewVIP",
  "section_ref": "wiki_page:computationalreviewvip-01-introduction",
  "source_kind": "review_finding",
  "source_path": "evidence/section_01_evidence_package.json",
  "source_refs": [
    "paper:paper-7f008ed47247"
  ],
  "source_span": "Adaptations of the axon initial segment in fast-spiking interneurons of the human neocortex.",
  "study_system": "human + rodent neocortex; AIS structural/functional comparison",
  "evidence_refs": [
    {
      "ref": "paper:paper-7f008ed47247"
    }
  ],
  "section_title": "Introduction",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
  },
  "evidence_summary": "Human neurosurgical specimens + IHC of AIS markers + correlated electrophysiology; comparison to rodent FS-INs.",
  "review_bundle_ref": "analysis_bundle:ab-2ce40c33e827",
  "replication_status": "replication_unknown",
  "review_package_ref": "analysis_bundle:ab-2ce40c33e827",
  "source_artifact_ref": "wiki_page:computationalreviewvip-01-introduction",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_01_evidence_package.json",
  "commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
}