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{
"n": 0,
"doi": "10.1038/s41386-022-01371-9",
"claim": "We find that pharmacological blockade of D1 dopamine receptor function reduces the METH-induced augmentation of IPSCs, suggesting a critical role for D1 dopamine signaling in METH-induced hypofrontality.",
"evidence": "Methamphetamine (METH) abuse is associated with the emergence of cognitive deficits and hypofrontality, a pathophysiological marker of many neuropsychiatric disorders that is produced by altered balance of local excitatory and inhibitory synaptic transmission. However, there is a dearth of informati",
"effect_size": null,
"text_access": "abstract_only",
"study_system": "rat cortex prefrontal cortex",
"replication_status": "independently_replicated",
"claim_source_sentence": "We find that pharmacological blockade of D1 dopamine receptor function reduces the METH-induced augmentation of IPSCs, suggesting a critical role for D1 dopamine signaling in METH-induced hypofrontality.",
"replication_evidence_dois": [
"10.1016/j.ynstr.2024.100628",
"10.1016/j.neuint.2011.05.004"
],
"effect_size_source_sentence": null
}- source_refs
[
"paper:paper-e58d322b4f63"
]
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[
{
"ref": "paper:paper-e58d322b4f63"
}
]- source_policy
{
"mode": "public_source_pointer_with_short_context",
"notes": [
"Local review repositories are read-only inputs.",
"SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
],
"source_commit_sha": "df9fc7e8d455b084152c9d713558dae0013cef21",
"source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV"
}- evidence_summary
Methamphetamine (METH) abuse is associated with the emergence of cognitive deficits and hypofrontality, a pathophysiological marker of many neuropsychiatric disorders that is produced by altered balance of local excitatory and inhibitory synaptic transmission. However, there is a dearth of informati