Details

scope
cebus monkey, retrograde transneuronal rabies virus tracing
claim_text
The subthalamic nucleus has a substantial disynaptic projection to the cerebellar cortex, providing a direct subcortical route by which basal ganglia output can influence cerebellar function independent of cerebral cortex.
section_id
section_07
source_url
https://github.com/AllenNeuralDynamics/ComputationalReviewLoops/blob/0632aae8abc141909207fe91f6349b9e36489c3b/evidence/section_07_evidence_package.json
effect_size
review_repo
ComputationalReviewLoops
section_ref
wiki_page:computationalreviewloops-07
source_kind
review_finding
source_path
evidence/section_07_evidence_package.json
source_span
We found that the subthalamic nucleus of the basal ganglia has a substantial disynaptic projection to the cerebellar cortex.
study_system
cebus monkey, retrograde transneuronal rabies virus tracing
section_title
Parallel Loop Channels: Motor, Limbic, Associative, and Beyond the Classic Three
review_bundle_ref
analysis_bundle:ab-d49e54403ef9
replication_status
replication_unknown
review_package_ref
analysis_bundle:ab-d49e54403ef9
source_artifact_ref
wiki_page:computationalreviewloops-07
origin_url
https://github.com/AllenNeuralDynamics/ComputationalReviewLoops/blob/0632aae8abc141909207fe91f6349b9e36489c3b/evidence/section_07_evidence_package.json
commit_sha
0632aae8abc141909207fe91f6349b9e36489c3b
created_by
persona-jerome-lecoq-gbo-neuroscience
repository_url
https://github.com/AllenNeuralDynamics/ComputationalReviewLoops
Raw fields (5)
raw_fields
{
  "n": 0,
  "doi": "10.1073/pnas.1000496107",
  "claim": "The subthalamic nucleus has a substantial disynaptic projection to the cerebellar cortex, providing a direct subcortical route by which basal ganglia output can influence cerebellar function independent of cerebral cortex.",
  "cite_key": "Bostan2010",
  "evidence": "Retrograde transneuronal rabies virus injections in cerebellar cortex of cebus monkeys revealed labeled neurons in the subthalamic nucleus, demonstrating a disynaptic STN→cerebellum pathway. Combined with prior demonstration of a dentate→striatum disynaptic projection, the data establish bidirectional subcortical basal ganglia–cerebellum communication.",
  "effect_size": "",
  "text_access": "abstract_only",
  "study_system": "cebus monkey, retrograde transneuronal rabies virus tracing",
  "source_cluster_id": "cluster_06",
  "replication_status": "replication_unknown",
  "claim_source_sentence": "We found that the subthalamic nucleus of the basal ganglia has a substantial disynaptic projection to the cerebellar cortex.",
  "replication_evidence_dois": [],
  "effect_size_source_sentence": null
}
source_refs
[
  "paper:paper-a741c9c4e6c1"
]
evidence_refs
[
  {
    "ref": "paper:paper-a741c9c4e6c1"
  }
]
source_policy
{
  "mode": "public_source_pointer_with_short_context",
  "notes": [
    "Local review repositories are read-only inputs.",
    "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
  ],
  "source_commit_sha": "0632aae8abc141909207fe91f6349b9e36489c3b",
  "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops"
}
evidence_summary
Retrograde transneuronal rabies virus injections in cerebellar cortex of cebus monkeys revealed labeled neurons in the subthalamic nucleus, demonstrating a disynaptic STN→cerebellum pathway. Combined with prior demonstration of a dentate→striatum disynaptic projection, the data establish bidirectional subcortical basal ganglia–cerebellum communication.

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