Details
- scope
- single-compartment HH model to morphologically detailed PV neuron models
- claim_text
- Perineuronal net degradation increases membrane capacitance (25-50%) reducing PV cell firing, but capacitance change alone is insufficient to explain firing rate reduction in detailed multi-compartment models
- section_id
- section_12_evidence_package
- source_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_12_evidence_package.json
- effect_size
- 25-50% increase in membrane capacitance
- review_repo
- ComputationalReviewPV
- section_ref
- wiki_page:computationalreviewpv-12
- source_kind
- review_finding
- source_path
- evidence/section_12_evidence_package.json
- source_span
- In all models, an increased cm lead to reduced firing, but the experimentally reported increase in cm was not alone sufficient to explain the experimentally reported reduction in firing rate.
- study_system
- single-compartment HH model to morphologically detailed PV neuron models
- section_title
- Computational Models of PV Circuit Function
- evidence_summary
- Simulations across single-compartment HH model to morphologically detailed PV neuron models
- review_bundle_ref
- analysis_bundle:ab-e6261c8263e7
- replication_status
- replication_unknown
- review_package_ref
- analysis_bundle:ab-e6261c8263e7
- source_artifact_ref
- wiki_page:computationalreviewpv-12
- origin_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_12_evidence_package.json
- commit_sha
- df9fc7e8d455b084152c9d713558dae0013cef21
- created_by
- persona-jerome-lecoq-gbo-neuroscience
- repository_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewPV
Raw fields (4)
- raw_fields
{ "n": 0, "doi": "10.1007/s10827-023-00849-9", "claim": "Perineuronal net degradation increases membrane capacitance (25-50%) reducing PV cell firing, but capacitance change alone is insufficient to explain firing rate reduction in detailed multi-compartment models", "evidence": "Simulations across single-compartment HH model to morphologically detailed PV neuron models", "effect_size": "25-50% increase in membrane capacitance", "text_access": "fulltext", "study_system": "single-compartment HH model to morphologically detailed PV neuron models", "replication_status": "replication_unknown", "claim_source_sentence": "In all models, an increased cm lead to reduced firing, but the experimentally reported increase in cm was not alone sufficient to explain the experimentally reported reduction in firing rate.", "replication_evidence_dois": [], "effect_size_source_sentence": "Tewari et al. (2018) found that degradation of PNNs induced a 25%-50% increase in membrane capacitance cm and a reduction in the firing rates of PV-cells." }- source_refs
[ "paper:paper-d6a5d21b353b" ]
- evidence_refs
[ { "ref": "paper:paper-d6a5d21b353b" } ]- source_policy
{ "mode": "public_source_pointer_with_short_context", "notes": [ "Local review repositories are read-only inputs.", "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose." ], "source_commit_sha": "df9fc7e8d455b084152c9d713558dae0013cef21", "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV" }