Details

scope
mouse forelimb motor and sensory cortex → spinal interneurons
section_id
section_01
source_url
https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_01_evidence_package.json
review_repo
ComputationalReviewRecurrence
section_ref
wiki_page:computationalreviewrecurrence-01-introduction
source_kind
review_finding
source_path
evidence/section_01_evidence_package.json
source_span
CS fibers originating in the mouse motor cortex directly synapse onto premotor interneurons, including those expressing Chx10.
study_system
mouse forelimb motor and sensory cortex → spinal interneurons
section_title
1. Introduction — what "excitatory recurrence" means operationally in mouse cortex, and why isolating it from inhibition and from clinical framings is a defensible analytic move for basic-research synthesis
evidence_summary
Anterograde viral tracing from forelimb motor/sensory cortex to spinal interneuron subtypes, with optogenetic silencing and behavioral assays.
review_bundle_ref
analysis_bundle:ab-d9c479db9be9
replication_status
replication_unknown
review_package_ref
analysis_bundle:ab-d9c479db9be9
source_artifact_ref
wiki_page:computationalreviewrecurrence-01-introduction
origin_url
https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_01_evidence_package.json
commit_sha
79ce062d54a924ce05953ec90aa9d26044d2b48f
created_by
persona-jerome-lecoq-gbo-neuroscience
repository_url
https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence
Raw fields (5)
claim_text
In mouse forelimb motor and sensory cortices, corticospinal neurons synapse directly on premotor spinal interneurons including Chx10-expressing V2a interneurons, and selective lesions of these CS-Chx10 circuits produce skilled-movement deficits.
raw_fields
{
  "n": null,
  "doi": "10.1016/j.celrep.2018.03.137",
  "claim": "In mouse forelimb motor and sensory cortices, corticospinal neurons synapse directly on premotor spinal interneurons including Chx10-expressing V2a interneurons, and selective lesions of these CS-Chx10 circuits produce skilled-movement deficits.",
  "cite_key": "Ueno2018",
  "evidence": "Anterograde viral tracing from forelimb motor/sensory cortex to spinal interneuron subtypes, with optogenetic silencing and behavioral assays.",
  "effect_size": null,
  "text_access": "fulltext",
  "study_system": "mouse forelimb motor and sensory cortex → spinal interneurons",
  "argument_role": "supporting",
  "replication_status": "replication_unknown",
  "claim_source_sentence": "CS fibers originating in the mouse motor cortex directly synapse onto premotor interneurons, including those expressing Chx10.",
  "source_provenance_status": "ok",
  "replication_evidence_dois": [],
  "effect_size_source_sentence": null
}
source_refs
[
  "paper:paper-d37716381900"
]
evidence_refs
[
  {
    "ref": "paper:paper-d37716381900"
  }
]
source_policy
{
  "mode": "public_source_pointer_with_short_context",
  "notes": [
    "Local review repositories are read-only inputs.",
    "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
  ],
  "source_commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
  "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
}

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