Version history

{
  "scope": "multiple neurological disorders (review)",
  "claim_text": "Mutations or abnormal regulation of Kv3 channels are associated with multiple neurological disorders including ataxias, epilepsies, schizophrenia, and Alzheimer's disease, reflecting the critical importance of these channels for normal brain function.",
  "raw_fields": {
    "n": 0,
    "doi": "10.1152/physrev.00002.2017",
    "claim": "Mutations or abnormal regulation of Kv3 channels are associated with multiple neurological disorders including ataxias, epilepsies, schizophrenia, and Alzheimer's disease, reflecting the critical importance of these channels for normal brain function.",
    "evidence": "Comprehensive review of Kv3 channel pathology across multiple diseases.",
    "effect_size": "Kv3 mutations/dysregulation linked to ataxias, epilepsies, schizophrenia, and Alzheimer's disease",
    "text_access": "fulltext",
    "study_system": "multiple neurological disorders (review)",
    "replication_status": "independently_replicated",
    "claim_source_sentence": "mutations or abnormal regulation of Kv3 channels are associated with neurological disorders such as ataxias, epilepsies, schizophrenia, and Alzheimer's disease.",
    "replication_evidence_dois": [
      "10.7554/elife.75316"
    ],
    "effect_size_source_sentence": "mutations or abnormal regulation of Kv3 channels are associated with neurological disorders such as ataxias, epilepsies, schizophrenia, and Alzheimer's disease."
  },
  "section_id": "section_05_evidence_package",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_05_evidence_package.json",
  "effect_size": "Kv3 mutations/dysregulation linked to ataxias, epilepsies, schizophrenia, and Alzheimer's disease",
  "review_repo": "ComputationalReviewPV",
  "section_ref": "wiki_page:computationalreviewpv-05",
  "source_kind": "review_finding",
  "source_path": "evidence/section_05_evidence_package.json",
  "source_refs": [
    "paper:paper-52be420ef14e"
  ],
  "source_span": "mutations or abnormal regulation of Kv3 channels are associated with neurological disorders such as ataxias, epilepsies, schizophrenia, and Alzheimer's disease.",
  "study_system": "multiple neurological disorders (review)",
  "evidence_refs": [
    {
      "ref": "paper:paper-52be420ef14e"
    }
  ],
  "section_title": "Intrinsic Electrophysiology: The Fast-Spiking Phenotype and Its Variants",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "df9fc7e8d455b084152c9d713558dae0013cef21",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV"
  },
  "evidence_summary": "Comprehensive review of Kv3 channel pathology across multiple diseases.",
  "review_bundle_ref": "analysis_bundle:ab-e6261c8263e7",
  "replication_status": "independently_replicated",
  "review_package_ref": "analysis_bundle:ab-e6261c8263e7",
  "source_artifact_ref": "wiki_page:computationalreviewpv-05",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_05_evidence_package.json",
  "commit_sha": "df9fc7e8d455b084152c9d713558dae0013cef21",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV"
}