Brief (5 ms) optogenetic photostimulation of the mouse hand evokes ~25 ms barra…

Brief (5 ms) optogenetic photostimulation of the mouse hand evokes ~25 ms barrages of cortical activity that arrive in S1 (latency ~15 ms) and then in M1 (~10 ms later) with the estimated S1→M1 corticocortical propagation 20-fold slower than the hand→S1 lemnisco-cortical pathway, and with M1 responses biased toward upper layers consistent with L2/3-dominated corticocortical input organization.

{
  "n": 0,
  "doi": "10.7554/elife.105112",
  "claim": "Brief (5 ms) optogenetic photostimulation of the mouse hand evokes ~25 ms barrages of cortical activity that arrive in S1 (latency ~15 ms) and then in M1 (~10 ms later) with the estimated S1→M1 corticocortical propagation 20-fold slower than the hand→S1 lemnisco-cortical pathway, and with M1 responses biased toward upper layers consistent with L2/3-dominated corticocortical input organization.",
  "cite_key": "PinaNovo2025",
  "evidence": "In-vivo multi-laminar silicon-probe recordings in S1 and M1 of awake/lightly-anesthetized mice combined with hand-targeted optogenetic photostimulation and pharmacological dissection.",
  "effect_size": "quantitative — 20-fold slower propagation speed corticocortical vs lemnisco-cortical",
  "text_access": "fulltext",
  "study_system": "mouse hand/forelimb S1 and M1, in vivo",
  "argument_role": "supporting",
  "replication_status": "independently_replicated",
  "claim_source_sentence": "The estimated propagation speed was 20-fold faster from hand to S1 than from S1 to M1. Amplitudes in M1 were strongly attenuated. Responses were typically triphasic, with suppression and rebound following the initial peak. Evoked activity in S1 was biased to middle layers, consistent with thalamocortical connectivity, while that in M1 was biased to upper layers, consistent with corticocortical connectivity",
  "source_provenance_status": "ok",
  "replication_evidence_dois": [
    "10.7554/eLife.66836"
  ],
  "effect_size_source_sentence": "The estimated propagation speed was 20-fold faster from hand to S1 than from S1 to M1"
}

[
  "paper:paper-fb6620a1a14d"
]

The estimated propagation speed was 20-fold faster from hand to S1 than from S1 to M1. Amplitudes in M1 were strongly attenuated. Responses were typically triphasic, with suppression and rebound following the initial peak. Evoked activity in S1 was biased to middle layers, consistent with thalamocortical connectivity, while that in M1 was biased to upper layers, consistent with corticocortical connectivity

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