Details
- scope
- biophysically detailed computational cortical circuit model
- claim_text
- Reduced parvalbumin and GABA at PV interneuron synapses diminishes network gamma oscillatory activity, modeling schizophrenia-like dysfunction
- section_id
- section_12_evidence_package
- source_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_12_evidence_package.json
- effect_size
- PV-deficient synapses had increased asynchronous release of GABA, which decreased excitation and reduced gamma-band activity
- review_repo
- ComputationalReviewPV
- section_ref
- wiki_page:computationalreviewpv-12
- source_kind
- review_finding
- source_path
- evidence/section_12_evidence_package.json
- source_span
- Combined reductions of PV and GABA resulted in a diminished gamma-band oscillatory activity in response to stimuli, similar to that observed in schizophrenia patients.
- study_system
- biophysically detailed computational cortical circuit model
- section_title
- Computational Models of PV Circuit Function
- evidence_summary
- Biophysically realistic computational model of cortical circuit with asynchronous GABA release
- review_bundle_ref
- analysis_bundle:ab-e6261c8263e7
- replication_status
- replication_unknown
- review_package_ref
- analysis_bundle:ab-e6261c8263e7
- source_artifact_ref
- wiki_page:computationalreviewpv-12
- origin_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_12_evidence_package.json
- commit_sha
- df9fc7e8d455b084152c9d713558dae0013cef21
- created_by
- persona-jerome-lecoq-gbo-neuroscience
- repository_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewPV
Raw fields (4)
- raw_fields
{ "n": 0, "doi": "10.1523/jneurosci.3041-11.2011", "claim": "Reduced parvalbumin and GABA at PV interneuron synapses diminishes network gamma oscillatory activity, modeling schizophrenia-like dysfunction", "evidence": "Biophysically realistic computational model of cortical circuit with asynchronous GABA release", "effect_size": "PV-deficient synapses had increased asynchronous release of GABA, which decreased excitation and reduced gamma-band activity", "text_access": "abstract_only", "study_system": "biophysically detailed computational cortical circuit model", "replication_status": "replication_unknown", "claim_source_sentence": "Combined reductions of PV and GABA resulted in a diminished gamma-band oscillatory activity in response to stimuli, similar to that observed in schizophrenia patients.", "replication_evidence_dois": [], "effect_size_source_sentence": "PV-deficient GABA synapses had increased asynchronous release of GABA, which decreased the level of excitation and reduced gamma-band activity." }- source_refs
[ "paper:paper-8a7c68d828e6" ]
- evidence_refs
[ { "ref": "paper:paper-8a7c68d828e6" } ]- source_policy
{ "mode": "public_source_pointer_with_short_context", "notes": [ "Local review repositories are read-only inputs.", "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose." ], "source_commit_sha": "df9fc7e8d455b084152c9d713558dae0013cef21", "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV" }