Version history

{
  "scope": "mouse V1 + computational modeling",
  "claim_text": "VIP and SST interneuron classes have *complementary* contrast tuning in V1: SST cells respond exclusively at high contrast (with weak direction/orientation selectivity), VIP cells respond exclusively at low contrast (with strong direction bias for front-to-back motion). Stabilized supralinear network (SSN) modeling extended to include both classes shows VIP–SST mutual antagonism regulates cortical gain — sensitivity to weak stimuli without compromising stability.",
  "raw_fields": {
    "n": null,
    "doi": "10.7554/elife.55130",
    "claim": "VIP and SST interneuron classes have *complementary* contrast tuning in V1: SST cells respond exclusively at high contrast (with weak direction/orientation selectivity), VIP cells respond exclusively at low contrast (with strong direction bias for front-to-back motion). Stabilized supralinear network (SSN) modeling extended to include both classes shows VIP–SST mutual antagonism regulates cortical gain — sensitivity to weak stimuli without compromising stability.",
    "title": null,
    "cite_key": "Millman2020",
    "evidence": "2P imaging + SSN modeling (Lee 2020)",
    "effect_size": "Complementary contrast tuning; SSN with VIP-SST mutual antagonism stable",
    "text_access": "fulltext",
    "study_system": "mouse V1 + computational modeling",
    "_source_cluster": "cluster_04_intrinsic_electrophysiology",
    "replication_status": "novel",
    "_source_cluster_index": 79,
    "claim_source_sentence": "SST neurons responded exclusively at high contrast whereas VIP neurons responded exclusively at low contrast with a strong preference for front-to-back motion.",
    "replication_evidence_dois": [],
    "effect_size_source_sentence": "Network modeling indicates that VIP-SST mutual antagonism regulates the gain of the cortex to achieve sensitivity to specific weak stimuli without compromising network stability."
  },
  "section_id": "section_05",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_05_evidence_package.json",
  "effect_size": "Complementary contrast tuning; SSN with VIP-SST mutual antagonism stable",
  "review_repo": "ComputationalReviewVIP",
  "section_ref": "wiki_page:computationalreviewvip-05-electrophysiology",
  "source_kind": "review_finding",
  "source_path": "evidence/section_05_evidence_package.json",
  "source_refs": [
    "paper:paper-f2c584233c97"
  ],
  "source_span": "SST neurons responded exclusively at high contrast whereas VIP neurons responded exclusively at low contrast with a strong preference for front-to-back motion.",
  "study_system": "mouse V1 + computational modeling",
  "evidence_refs": [
    {
      "ref": "paper:paper-f2c584233c97"
    }
  ],
  "section_title": "Intrinsic Electrophysiology",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
  },
  "evidence_summary": "2P imaging + SSN modeling (Lee 2020)",
  "review_bundle_ref": "analysis_bundle:ab-2ce40c33e827",
  "replication_status": "novel",
  "review_package_ref": "analysis_bundle:ab-2ce40c33e827",
  "source_artifact_ref": "wiki_page:computationalreviewvip-05-electrophysiology",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_05_evidence_package.json",
  "commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
}