Mouse motor-cortex corticospinal (PT) pyramidal neurons exhibit class-specific…

Mouse motor-cortex corticospinal (PT) pyramidal neurons exhibit class-specific intrinsic electrophysiology: relatively fast action potentials (~0.65 ms half-width, narrower than neighboring callosally-projecting corticostriatal IT neurons), nearly linear f-I relationships, regular firing, and frequency-independent AP width — providing a cell-type-intrinsic identification signature for PT in L5B.

{
  "n": 0,
  "doi": "10.1093/cercor/bhs184",
  "claim": "Mouse motor-cortex corticospinal (PT) pyramidal neurons exhibit class-specific intrinsic electrophysiology: relatively fast action potentials (~0.65 ms half-width, narrower than neighboring callosally-projecting corticostriatal IT neurons), nearly linear f-I relationships, regular firing, and frequency-independent AP width — providing a cell-type-intrinsic identification signature for PT in L5B.",
  "cite_key": "Suter2013",
  "evidence": "Whole-cell patch-clamp recording of retrogradely-labeled corticospinal and corticostriatal L5B neurons in mouse M1 slices.",
  "effect_size": "quantitative — AP half-width 0.65 ± 0.13 ms in PT, narrower than IT neighbors",
  "text_access": "abstract_only",
  "study_system": "mouse primary motor cortex L5B corticospinal pyramidal neurons",
  "argument_role": "supporting",
  "replication_status": "independently_replicated",
  "claim_source_sentence": "Corticospinal neurons fired relatively fast action potentials (APs; width at half-maximum 0.65 ± 0.13 ms, mean ± standard deviation [SD]) compared with neighboring callosally projecting corticostriatal neurons",
  "source_provenance_status": "non_substring_match",
  "replication_evidence_dois": [
    "10.3389/fncel.2013.00174"
  ],
  "effect_size_source_sentence": "width at half-maximum 0.65 ± 0.13 ms"
}

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