Details
- scope
- review of circuit models in schizophrenia
- claim_text
- NMDAR antagonists reduce excitation of fast-spiking interneurons causing pyramidal cell disinhibition; disinhibition decreases gamma oscillation power and may produce negative and cognitive symptoms
- section_id
- section_10_evidence_package
- source_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_10_evidence_package.json
- effect_size
- NMDAR antagonists reduce parvalbumin and GAD67 in animal models
- review_repo
- ComputationalReviewPV
- section_ref
- wiki_page:computationalreviewpv-10
- source_kind
- review_finding
- source_path
- evidence/section_10_evidence_package.json
- source_span
- Disinhibition decreases the power of gamma oscillation and might thereby produce negative and cognitive symptoms.
- study_system
- review of circuit models in schizophrenia
- section_title
- Oscillations and Network Dynamics: Gamma, Ripples, and Synchrony
- evidence_summary
- NMDAR antagonists reduce excitation of fast-spiking interneurons causing pyramidal cell disinhibition; disinhibition decreases gamma oscillation power and may produce negative and cognitive symptoms
- review_bundle_ref
- analysis_bundle:ab-e6261c8263e7
- replication_status
- independently_replicated
- review_package_ref
- analysis_bundle:ab-e6261c8263e7
- source_artifact_ref
- wiki_page:computationalreviewpv-10
- origin_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_10_evidence_package.json
- commit_sha
- df9fc7e8d455b084152c9d713558dae0013cef21
- created_by
- persona-jerome-lecoq-gbo-neuroscience
- repository_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewPV
Raw fields (4)
- raw_fields
{ "n": 0, "doi": "10.1016/j.tins.2008.02.005", "claim": "NMDAR antagonists reduce excitation of fast-spiking interneurons causing pyramidal cell disinhibition; disinhibition decreases gamma oscillation power and may produce negative and cognitive symptoms", "evidence": "NMDAR antagonists reduce excitation of fast-spiking interneurons causing pyramidal cell disinhibition; disinhibition decreases gamma oscillation power and may produce negative and cognitive symptoms", "effect_size": "NMDAR antagonists reduce parvalbumin and GAD67 in animal models", "text_access": "fulltext", "study_system": "review of circuit models in schizophrenia", "replication_status": "independently_replicated", "claim_source_sentence": "Disinhibition decreases the power of gamma oscillation and might thereby produce negative and cognitive symptoms.", "replication_evidence_dois": [ "10.1038/mp.2011.31", "10.1016/j.biopsych.2015.07.005" ], "effect_size_source_sentence": "In animal models, NMDAR antagonists reduce parvalbumin and GAD67, as found in schizophrenia." }- source_refs
[ "paper:paper-2e307cde19ef" ]
- evidence_refs
[ { "ref": "paper:paper-2e307cde19ef" } ]- source_policy
{ "mode": "public_source_pointer_with_short_context", "notes": [ "Local review repositories are read-only inputs.", "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose." ], "source_commit_sha": "df9fc7e8d455b084152c9d713558dae0013cef21", "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV" }