In mouse barrel cortex, vM1 long-range inputs preferentially excite VIP interne…

In mouse barrel cortex, vM1 long-range inputs preferentially excite VIP interneurons over pyramidal neurons (~2.9× ratio), and VIP optogenetic activation produces IPSCs in SST interneurons that are >4× larger than in nearby pyramids (440.81±6.96 pA vs 111.40±6.11 pA), establishing a vM1→VIP→SST disinhibitory motif during whisking.

{
  "n": null,
  "doi": "10.1038/nn.3544",
  "claim": "In mouse barrel cortex, vM1 long-range inputs preferentially excite VIP interneurons over pyramidal neurons (~2.9× ratio), and VIP optogenetic activation produces IPSCs in SST interneurons that are >4× larger than in nearby pyramids (440.81±6.96 pA vs 111.40±6.11 pA), establishing a vM1→VIP→SST disinhibitory motif during whisking.",
  "title": null,
  "cite_key": "Lee2013",
  "evidence": "Whole-cell paired recordings + ChR2 photo-stimulation of vM1 axons or local VIP cells in S1 barrel cortex slices; in vivo cell-attached during whisking.",
  "effect_size": "vM1→VIP/Pyr ratio = 2.88 ± 1.12; VIP→SST/Pyr amplitude ratio = 5.06 ± 2.45; charge ratio = 6.44 ± 3.61; whisking firing-rate ratio for VIP = 3.3 ± 1.23.",
  "text_access": "fulltext",
  "study_system": "mouse S1 barrel cortex; in vitro slice + in vivo head-fixed",
  "_source_cluster": "cluster_05_synaptic_connectivity",
  "replication_status": "independently_replicated",
  "_source_cluster_index": 2,
  "claim_source_sentence": "In contrast with fast-spiking interneurons, photo-stimulation of VIP interneurons generated IPSCs more than fourfold larger in a SST interneuron than in the simultaneously recorded pyramidal neuron (pyramidal, 111.40 ± 6.11 pA; SST, 440.81 ± 6.96 pA; P < 0.001, Mann-Whitney U test; ).",
  "replication_evidence_dois": [
    "10.1038/nn.3446",
    "10.1038/nature12676"
  ],
  "effect_size_source_sentence": "As a population, VIP interneurons provided significantly larger inhibition to SST interneurons than to pyramidal neurons (SST to pyramidal ratio: amplitude = 5.06 ± 2.45, P = 0.01; charge = 6.44 ± 3.61, P = 0.01; Wilcoxon signed-rank test; )."
}

[
  "paper:paper-f02f24cb44ff"
]

In contrast with fast-spiking interneurons, photo-stimulation of VIP interneurons generated IPSCs more than fourfold larger in a SST interneuron than in the simultaneously recorded pyramidal neuron (pyramidal, 111.40 ± 6.11 pA; SST, 440.81 ± 6.96 pA; P < 0.001, Mann-Whitney U test; ).

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    "ref": "paper:paper-f02f24cb44ff"
  }
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  "notes": [
    "Local review repositories are read-only inputs.",
    "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
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  "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
  "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
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