Version history

{
  "scope": "human fetal cortex (10-20 weeks PCW); scRNA-seq + scATAC-seq; ASO perturbation",
  "claim_text": "A single-cell atlas of ~250,000 cells from 30 human fetal cortices (15 Down syndrome, 15 control; 10–20 weeks postconception) identifies subtype-specific reduction of RORB+ and FOXP1+ excitatory neurons in DS, with chromosome 21 transcription factors BACH1, PKNOX1, and GABPA emerging as dosage-sensitive hubs regulating intellectual-disability-linked genes; antisense-mediated TF normalization partially rescued target gene expression.",
  "raw_fields": {
    "n": 250000,
    "doi": "10.1038/s41591-026-04211-1",
    "claim": "A single-cell atlas of ~250,000 cells from 30 human fetal cortices (15 Down syndrome, 15 control; 10–20 weeks postconception) identifies subtype-specific reduction of RORB+ and FOXP1+ excitatory neurons in DS, with chromosome 21 transcription factors BACH1, PKNOX1, and GABPA emerging as dosage-sensitive hubs regulating intellectual-disability-linked genes; antisense-mediated TF normalization partially rescued target gene expression.",
    "title": null,
    "cite_key": "Lattke2026",
    "evidence": "Single-cell transcriptomic + chromatin accessibility profiling of ~250,000 cells from 15 DS and 15 control human fetal cortices; ASO TF perturbation in human neural progenitors.",
    "effect_size": null,
    "text_access": "abstract_only",
    "study_system": "human fetal cortex (10-20 weeks PCW); scRNA-seq + scATAC-seq; ASO perturbation",
    "target_section": "section_11",
    "_source_cluster": "cluster_01_molecular_taxonomy",
    "replication_status": "replication_unknown",
    "_source_cluster_index": 96,
    "claim_source_sentence": "Our analysis revealed a subtype-specific reduction in RORB- and FOXP1-expressing excitatory neurons and widespread disruption of neurodevelopmental transcriptional programs. Chromosome 21 transcription factors BACH1, PKNOX1 and GABPA emerged as dosage-sensitive hubs regulating genes linked to intellectual disability.",
    "replication_evidence_dois": [],
    "effect_size_source_sentence": null
  },
  "section_id": "section_11",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_11_evidence_package.json",
  "effect_size": null,
  "review_repo": "ComputationalReviewVIP",
  "section_ref": "wiki_page:computationalreviewvip-11-disease-translational",
  "source_kind": "review_finding",
  "source_path": "evidence/section_11_evidence_package.json",
  "source_refs": [
    "paper:9354c026-33f1-4701-b47d-64ce038e7e37"
  ],
  "source_span": "Our analysis revealed a subtype-specific reduction in RORB- and FOXP1-expressing excitatory neurons and widespread disruption of neurodevelopmental transcriptional programs. Chromosome 21 transcription factors BACH1, PKNOX1 and GABPA emerged as dosage-sensitive hubs regulating genes linked to intellectual disability.",
  "study_system": "human fetal cortex (10-20 weeks PCW); scRNA-seq + scATAC-seq; ASO perturbation",
  "evidence_refs": [
    {
      "ref": "paper:9354c026-33f1-4701-b47d-64ce038e7e37"
    }
  ],
  "section_title": "Species Differences, Human Relevance, and Disease",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
  },
  "evidence_summary": "Single-cell transcriptomic + chromatin accessibility profiling of ~250,000 cells from 15 DS and 15 control human fetal cortices; ASO TF perturbation in human neural progenitors.",
  "review_bundle_ref": "analysis_bundle:ab-2ce40c33e827",
  "replication_status": "replication_unknown",
  "review_package_ref": "analysis_bundle:ab-2ce40c33e827",
  "source_artifact_ref": "wiki_page:computationalreviewvip-11-disease-translational",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_11_evidence_package.json",
  "commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
}