Version history

{
  "scope": "vip-interneurons",
  "claim_text": "Hippocampal CA1 VIP interneurons form functional subpopulations whose activity is shaped by behavioral states and task demands, and optogenetic manipulation shows VIP disinhibition is necessary for goal-oriented spatial learning — extending neuromodulator-driven VIP recruitment beyond cortex to hippocampus.",
  "raw_fields": {
    "n": null,
    "doi": "10.1016/j.neuron.2019.01.009",
    "year": "2019",
    "claim": "Hippocampal CA1 VIP interneurons form functional subpopulations whose activity is shaped by behavioral states and task demands, and optogenetic manipulation shows VIP disinhibition is necessary for goal-oriented spatial learning — extending neuromodulator-driven VIP recruitment beyond cortex to hippocampus.",
    "title": "Vasoactive Intestinal Polypeptide-Expressing Interneurons in the Hippocampus Support Goal-Oriented Spatial Learning",
    "journal": "",
    "species": "mouse",
    "cite_key": "Turi2019",
    "evidence": "Chronic two-photon Ca2+ imaging + optogenetics in CA1 of mice during random foraging vs. goal-oriented tasks.",
    "effect_size": "VIP silencing impaired goal-directed learning and altered place-cell representations.",
    "text_access": "fulltext",
    "_source_cluster": "cluster_13_neuromodulation",
    "replication_status": "single_study",
    "_source_cluster_index": 31,
    "claim_source_sentence": "VIP+ INs in hippocampal area CA1 form functional subpopulations defined by their modulation by behavioral states and task demands.",
    "replication_evidence_dois": [],
    "effect_size_source_sentence": "Optogenetic manipulations of VIP+ INs and computational modeling further showed that VIP+ disinhibition is necessary for goal-directed learning and related reorganization of hippocampal pyramidal cell population dynamics."
  },
  "section_id": "section_08",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_08_evidence_package.json",
  "effect_size": "VIP silencing impaired goal-directed learning and altered place-cell representations.",
  "review_repo": "ComputationalReviewVIP",
  "section_ref": "wiki_page:computationalreviewvip-08-in-vivo-behavior",
  "source_kind": "review_finding",
  "source_path": "evidence/section_08_evidence_package.json",
  "source_refs": [
    "paper:paper-c0f52ec4cd1c"
  ],
  "source_span": "VIP+ INs in hippocampal area CA1 form functional subpopulations defined by their modulation by behavioral states and task demands.",
  "study_system": null,
  "evidence_refs": [
    {
      "ref": "paper:paper-c0f52ec4cd1c"
    }
  ],
  "section_title": "In Vivo Function During Behavior",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
  },
  "evidence_summary": "Chronic two-photon Ca2+ imaging + optogenetics in CA1 of mice during random foraging vs. goal-oriented tasks.",
  "review_bundle_ref": "analysis_bundle:ab-2ce40c33e827",
  "replication_status": "single_study",
  "review_package_ref": "analysis_bundle:ab-2ce40c33e827",
  "source_artifact_ref": "wiki_page:computationalreviewvip-08-in-vivo-behavior",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_08_evidence_package.json",
  "commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
}