Version history

{
  "scope": "vip-interneurons",
  "claim_text": "Cortical interneurons express high levels of opioid receptors, positioning opioid signaling as a critical regulator of inhibitory transmission; however, we lack a complete understanding of how classical opioid receptor systems regulate prefrontal cortex (PFC) microcircuitry.",
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    "n": null,
    "doi": "10.1523/jneurosci.1963-24.2025",
    "pmid": "40393805",
    "tags": [
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    ],
    "year": "2025",
    "claim": "Cortical interneurons express high levels of opioid receptors, positioning opioid signaling as a critical regulator of inhibitory transmission; however, we lack a complete understanding of how classical opioid receptor systems regulate prefrontal cortex (PFC) microcircuitry.",
    "pmcid": "PMC12225597",
    "round": 3,
    "title": "Opioid Receptors Modulate Inhibition within the Prefrontal Cortex through Dissociable Cellular and Molecular Mechanisms.",
    "authors": "Cole RH, Allichon MC, Joffe ME.",
    "journal": "",
    "citation": "Cole RH, Allichon MC, Joffe ME. (2025). . 10.1523/jneurosci.1963-24.2025",
    "cite_key": "Cole2025",
    "effect_size": null,
    "text_access": "fulltext",
    "citedByCount": 1,
    "isOpenAccess": "N",
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    "claim_source_sentence": "Cortical interneurons express high levels of opioid receptors, positioning opioid signaling as a critical regulator of inhibitory transmission; however, we lack a complete understanding of how classical opioid receptor systems regulate prefrontal cortex (PFC) microcircuitry."
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  "section_id": "section_13",
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  "study_system": null,
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  "section_title": "Synthesis and Conclusion: Reassessing the Canonical VIP Disinhibitor",
  "source_policy": {
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    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
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}