Version history

{
  "scope": "mouse motor cortex (M1); Patch-seq",
  "claim_text": "Scala et al. (2021) used Patch-seq on >1,300 mouse motor cortex (M1) neurons to show that broad transcriptomic families (Vip, Pvalb, Sst) had distinct non-overlapping morpho-electric phenotypes, but individual t-types within a family were not well separated in morpho-electric space, indicating continuous phenotypic variation within VIP and other subclasses.",
  "raw_fields": {
    "n": 1329,
    "doi": "10.1038/s41586-020-2907-3",
    "claim": "Scala et al. (2021) used Patch-seq on >1,300 mouse motor cortex (M1) neurons to show that broad transcriptomic families (Vip, Pvalb, Sst) had distinct non-overlapping morpho-electric phenotypes, but individual t-types within a family were not well separated in morpho-electric space, indicating continuous phenotypic variation within VIP and other subclasses.",
    "title": null,
    "cite_key": "Scala2021",
    "evidence": "Patch-seq on >1,300 cells from adult mouse M1; subclass-level morphoelectric separation robust; t-type-level separation continuous (e.g., Vip subtypes form a continuum rather than discrete clusters), challenging strict t-type/MET-type 1:1 correspondence below the subclass level.",
    "effect_size": null,
    "text_access": "fulltext",
    "study_system": "mouse motor cortex (M1); Patch-seq",
    "target_section": "section_11",
    "_source_cluster": "cluster_01_molecular_taxonomy",
    "replication_status": "replicated",
    "_source_cluster_index": 34,
    "claim_source_sentence": "We found that, although broad families of transcriptomic types (those expressing Vip, Pvalb, Sst and so on) had distinct and essentially non-overlapping morpho-electric phenotypes, individual transcriptomic types within the same family were not well separated in the morpho-electric space."
  },
  "section_id": "section_02",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_02_evidence_package.json",
  "effect_size": null,
  "review_repo": "ComputationalReviewVIP",
  "section_ref": "wiki_page:computationalreviewvip-02-classification",
  "source_kind": "review_finding",
  "source_path": "evidence/section_02_evidence_package.json",
  "source_refs": [
    "paper:paper-be132b319290"
  ],
  "source_span": "We found that, although broad families of transcriptomic types (those expressing Vip, Pvalb, Sst and so on) had distinct and essentially non-overlapping morpho-electric phenotypes, individual transcriptomic types within the same family were not well separated in the morpho-electric space.",
  "study_system": "mouse motor cortex (M1); Patch-seq",
  "evidence_refs": [
    {
      "ref": "paper:paper-be132b319290"
    }
  ],
  "section_title": "Molecular Identity and Transcriptomic Taxonomy",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
  },
  "evidence_summary": "Patch-seq on >1,300 cells from adult mouse M1; subclass-level morphoelectric separation robust; t-type-level separation continuous (e.g., Vip subtypes form a continuum rather than discrete clusters), challenging strict t-type/MET-type 1:1 correspondence below the subclass level.",
  "review_bundle_ref": "analysis_bundle:ab-2ce40c33e827",
  "replication_status": "replicated",
  "review_package_ref": "analysis_bundle:ab-2ce40c33e827",
  "source_artifact_ref": "wiki_page:computationalreviewvip-02-classification",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_02_evidence_package.json",
  "commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
}