Version history

{
  "scope": "mouse ALM and ventromedial thalamus; two-photon axonal imaging plus chemo-/opto-genetic manipulation in a tactile-cued licking task",
  "claim_text": "In mice performing tactile-cued licking, ventromedial-thalamus axon terminals in ALM are transiently active during licking and their activity predicts the timing of the first lick; chemogenetic or optogenetic manipulation of VM→ALM axons facilitates initiation of cue-triggered and impulsive licks, identifying a thalamocortical pathway that contributes a movement-initiation (vigor) signal to ALM during planned licking.",
  "raw_fields": {
    "n": 0,
    "doi": "10.1016/j.cub.2021.06.089",
    "claim": "In mice performing tactile-cued licking, ventromedial-thalamus axon terminals in ALM are transiently active during licking and their activity predicts the timing of the first lick; chemogenetic or optogenetic manipulation of VM→ALM axons facilitates initiation of cue-triggered and impulsive licks, identifying a thalamocortical pathway that contributes a movement-initiation (vigor) signal to ALM during planned licking.",
    "cite_key": "Takahashi2021",
    "evidence": "We found that inactivation of ALM delayed the initiation of cued licking. Chemogenetic and optogenetic manipulation of VM axons in ALM indicated that VM inputs facilitate the initiation of cue-triggered and impulsive licking in trained mice.",
    "effect_size": "",
    "text_access": "fulltext",
    "study_system": "mouse ALM and ventromedial thalamus; two-photon axonal imaging plus chemo-/opto-genetic manipulation in a tactile-cued licking task",
    "argument_role": "supporting",
    "replication_status": "single_lab",
    "claim_source_sentence": "Two-photon Ca imaging of VM axons revealed that the majority of the axon terminals in ALM were transiently active during licking. Their activity was predictive of the time of the first lick.",
    "source_provenance_status": "ok",
    "replication_evidence_dois": [],
    "effect_size_source_sentence": null
  },
  "section_id": "section_10",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_10_evidence_package.json",
  "effect_size": "",
  "review_repo": "ComputationalReviewRecurrence",
  "section_ref": "wiki_page:computationalreviewrecurrence-10-persistent-activity",
  "source_kind": "review_finding",
  "source_path": "evidence/section_10_evidence_package.json",
  "source_refs": [
    "paper:paper-2f1dac206724"
  ],
  "source_span": "Two-photon Ca imaging of VM axons revealed that the majority of the axon terminals in ALM were transiently active during licking. Their activity was predictive of the time of the first lick.",
  "study_system": "mouse ALM and ventromedial thalamus; two-photon axonal imaging plus chemo-/opto-genetic manipulation in a tactile-cued licking task",
  "evidence_refs": [
    {
      "ref": "paper:paper-2f1dac206724"
    }
  ],
  "section_title": "10. Physiological signature II — persistent activity and attractor dynamics supported by E→E recurrence (delay-period activity in mouse PFC/ALM, working memory, head-direction)",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
  },
  "evidence_summary": "We found that inactivation of ALM delayed the initiation of cued licking. Chemogenetic and optogenetic manipulation of VM axons in ALM indicated that VM inputs facilitate the initiation of cue-triggered and impulsive licking in trained mice.",
  "review_bundle_ref": "analysis_bundle:ab-d9c479db9be9",
  "replication_status": "single_lab",
  "review_package_ref": "analysis_bundle:ab-d9c479db9be9",
  "source_artifact_ref": "wiki_page:computationalreviewrecurrence-10-persistent-activity",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_10_evidence_package.json",
  "commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
}