Version history

{
  "scope": "mouse PFC slice; midline/paralaminar matrix → L1 (channelrhodopsin)",
  "claim_text": "Matrix-thalamic axons projecting to layer 1 of mouse PFC transmit fast, high-fidelity synaptic signals that preferentially drive L1 inhibitory interneurons and produce sustained responses on repetitive stimulation, contrary to the view that matrix inputs are weak/diffuse modulators.",
  "raw_fields": {
    "n": 0,
    "doi": "10.1523/jneurosci.3231-12.2012",
    "claim": "Matrix-thalamic axons projecting to layer 1 of mouse PFC transmit fast, high-fidelity synaptic signals that preferentially drive L1 inhibitory interneurons and produce sustained responses on repetitive stimulation, contrary to the view that matrix inputs are weak/diffuse modulators.",
    "cite_key": "Cruikshank2012",
    "evidence": "Channelrhodopsin expression in midline/paralaminar (matrix) thalamic neurons with optical activation of L1 axons in mouse PFC slices.",
    "effect_size": "Matrix L1 TC inputs sustained signals far longer than core sensory TC pathways during repetitive stimulation",
    "text_access": "fulltext",
    "study_system": "mouse PFC slice; midline/paralaminar matrix → L1 (channelrhodopsin)",
    "source_cluster_id": "cluster_05",
    "replication_status": "independently_replicated",
    "claim_source_sentence": "Knowledge of thalamocortical (TC) processing comes mainly from studying core thalamic systems that project to middle layers of primary sensory cortices.",
    "replication_evidence_dois": [
      "10.1093/cercor/bhn259",
      "10.1016/j.neuron.2020.10.031"
    ],
    "effect_size_source_sentence": "However, most thalamic relay neurons comprise a matrix of cells that are densest in the \"nonspecific\" thalamic nuclei and usually target layer 1 (L1) of multiple cortical areas."
  },
  "section_id": "section_06",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops/blob/0632aae8abc141909207fe91f6349b9e36489c3b/evidence/section_06_evidence_package.json",
  "effect_size": "Matrix L1 TC inputs sustained signals far longer than core sensory TC pathways during repetitive stimulation",
  "review_repo": "ComputationalReviewLoops",
  "section_ref": "wiki_page:computationalreviewloops-06",
  "source_kind": "review_finding",
  "source_path": "evidence/section_06_evidence_package.json",
  "source_refs": [
    "paper:paper-49604016d900"
  ],
  "source_span": "Knowledge of thalamocortical (TC) processing comes mainly from studying core thalamic systems that project to middle layers of primary sensory cortices.",
  "study_system": "mouse PFC slice; midline/paralaminar matrix → L1 (channelrhodopsin)",
  "evidence_refs": [
    {
      "ref": "paper:paper-49604016d900"
    }
  ],
  "section_title": "Thalamic Feedback: Closing the Loop",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "0632aae8abc141909207fe91f6349b9e36489c3b",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops"
  },
  "evidence_summary": "Channelrhodopsin expression in midline/paralaminar (matrix) thalamic neurons with optical activation of L1 axons in mouse PFC slices.",
  "review_bundle_ref": "analysis_bundle:ab-d49e54403ef9",
  "replication_status": "independently_replicated",
  "review_package_ref": "analysis_bundle:ab-d49e54403ef9",
  "source_artifact_ref": "wiki_page:computationalreviewloops-06",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops/blob/0632aae8abc141909207fe91f6349b9e36489c3b/evidence/section_06_evidence_package.json",
  "commit_sha": "0632aae8abc141909207fe91f6349b9e36489c3b",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops"
}