- raw_fields
{
"n": 0,
"doi": "10.3389/fnsys.2025.1673195",
"claim": "The NERD model: reflex circuit dysfunction as a systems-level driver of persistent post-concussion symptoms",
"cite_key": "Antonucci2026",
"evidence": "Persistent post-concussive symptoms are often attributed to diffuse cortical dysfunction, yet this perspective may overlook key systems-level mechanisms. We propose a conceptual framework in which dysfunction arises from the dynamic interplay among five functional nodes: the sensory interface, reflex-brain stem hub, cerebellar module, basal ganglia-thalamic modulator, and cerebral cortex. Grounded",
"effect_size": null,
"text_access": "fulltext",
"study_system": "mammalian, thalamocortical",
"source_cluster_id": "cluster_05",
"replication_status": "replication_unknown",
"claim_source_sentence": "When higher-order “node” structures like the thalamus or cerebellum are impaired, their regulatory control over subcortical reflex circuits diminishes.",
"replication_evidence_dois": [],
"effect_size_source_sentence": null
}- source_refs
[
"paper:paper-003d1a16b7a1"
]
- evidence_refs
[
{
"ref": "paper:paper-003d1a16b7a1"
}
]- source_policy
{
"mode": "public_source_pointer_with_short_context",
"notes": [
"Local review repositories are read-only inputs.",
"SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
],
"source_commit_sha": "0632aae8abc141909207fe91f6349b9e36489c3b",
"source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops"
}- evidence_summary
Persistent post-concussive symptoms are often attributed to diffuse cortical dysfunction, yet this perspective may overlook key systems-level mechanisms. We propose a conceptual framework in which dysfunction arises from the dynamic interplay among five functional nodes: the sensory interface, reflex-brain stem hub, cerebellar module, basal ganglia-thalamic modulator, and cerebral cortex. Grounded