Version history

{
  "scope": "mouse PFC/frontal cortex",
  "claim_text": "Using several Cre mouse lines, we performed cellular-resolution Ca 2+ imaging from excitatory pyramidal (PYR) neurons as well as three distinct subtypes of inhibitory interneurons: parvalbumin-positive (PV + ), somatostatin-positive (SST + ), and vasoactive intestinal peptide-positive (VIP + ) neurons, which together comprise 85% of all GABAergic neurons in the cortex ( Rudy et al., 2011; Xu et al., 2010 ).",
  "raw_fields": {
    "n": 20,
    "doi": "10.1016/j.neuron.2015.06.021",
    "year": "2015",
    "claim": "Using several Cre mouse lines, we performed cellular-resolution Ca 2+ imaging from excitatory pyramidal (PYR) neurons as well as three distinct subtypes of inhibitory interneurons: parvalbumin-positive (PV + ), somatostatin-positive (SST + ), and vasoactive intestinal peptide-positive (VIP + ) neurons, which together comprise 85% of all GABAergic neurons in the cortex ( Rudy et al., 2011; Xu et al., 2010 ).",
    "title": null,
    "journal": "Neuron",
    "cite_key": "Pinto2015",
    "evidence": "Cell-Type-Specific Activity in Prefrontal Cortex during Goal-Directed Behavior",
    "effect_size": null,
    "text_access": "fulltext",
    "first_author": "Pinto",
    "study_system": "mouse PFC/frontal cortex",
    "_source_cluster": "cluster_06_disinhibition_circuit",
    "author_list_short": "Pinto, Dan",
    "replication_status": "replicated",
    "_source_cluster_index": 7,
    "claim_source_sentence": "Using several Cre mouse lines, we performed cellular-resolution Ca 2+ imaging from excitatory pyramidal (PYR) neurons as well as three distinct subtypes of inhibitory interneurons: parvalbumin-positive (PV + ), somatostatin-positive (SST + ), and vasoactive intestinal peptide-positive (VIP + ) neurons, which together comprise 85% of all GABAergic neurons in the cortex ( Rudy et al., 2011; Xu et al., 2010 ).",
    "replication_evidence_dois": [
      "10.1126/science.1254126",
      "10.1038/nn.4554",
      "10.1126/science.aag2599"
    ],
    "effect_size_source_sentence": "Figure 1 Experimental Approach (A) Schematic of the behavioral task. (B) Learning curves of an example mouse (left) and population of imaged mice (right, n = 20)."
  },
  "section_id": "section_07",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_07_evidence_package.json",
  "effect_size": null,
  "review_repo": "ComputationalReviewVIP",
  "section_ref": "wiki_page:computationalreviewvip-07-disinhibition-framework",
  "source_kind": "review_finding",
  "source_path": "evidence/section_07_evidence_package.json",
  "source_refs": [
    "paper:paper-6fb6c7efe883"
  ],
  "source_span": "Using several Cre mouse lines, we performed cellular-resolution Ca 2+ imaging from excitatory pyramidal (PYR) neurons as well as three distinct subtypes of inhibitory interneurons: parvalbumin-positive (PV + ), somatostatin-positive (SST + ), and vasoactive intestinal peptide-positive (VIP + ) neurons, which together comprise 85% of all GABAergic neurons in the cortex ( Rudy et al., 2011; Xu et al., 2010 ).",
  "study_system": "mouse PFC/frontal cortex",
  "evidence_refs": [
    {
      "ref": "paper:paper-6fb6c7efe883"
    }
  ],
  "section_title": "Local Circuit Motifs and the Disinhibition Framework",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
  },
  "evidence_summary": "Cell-Type-Specific Activity in Prefrontal Cortex during Goal-Directed Behavior",
  "review_bundle_ref": "analysis_bundle:ab-2ce40c33e827",
  "replication_status": "replicated",
  "review_package_ref": "analysis_bundle:ab-2ce40c33e827",
  "source_artifact_ref": "wiki_page:computationalreviewvip-07-disinhibition-framework",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_07_evidence_package.json",
  "commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
}