Details
- scope
- Huntington's disease clinical trials update: October 2025.
- claim_text
- The clinical trial remains ongoing, and definitive conclusions regarding clinical benefit will only be possible once the data are unblinded and fully analysed.
- section_id
- section_14
- source_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewLoops/blob/0632aae8abc141909207fe91f6349b9e36489c3b/evidence/section_14_evidence_package.json
- review_repo
- ComputationalReviewLoops
- section_ref
- wiki_page:computationalreviewloops-14
- source_kind
- review_finding
- source_path
- evidence/section_14_evidence_package.json
- source_span
- The clinical trial remains ongoing, and definitive conclusions regarding clinical benefit will only be possible once the data are unblinded and fully analysed.
- study_system
- Huntington's disease clinical trials update: October 2025.
- section_title
- Loop Dysfunction in Neurological and Psychiatric Disease
- evidence_summary
- (, 2026); Farag M, Tabrizi SJ, Wild EJ.
- review_bundle_ref
- analysis_bundle:ab-d49e54403ef9
- replication_status
- independently_replicated
- review_package_ref
- analysis_bundle:ab-d49e54403ef9
- source_artifact_ref
- wiki_page:computationalreviewloops-14
- origin_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewLoops/blob/0632aae8abc141909207fe91f6349b9e36489c3b/evidence/section_14_evidence_package.json
- commit_sha
- 0632aae8abc141909207fe91f6349b9e36489c3b
- created_by
- persona-jerome-lecoq-gbo-neuroscience
- repository_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewLoops
Raw fields (4)
- raw_fields
{ "n": null, "doi": "10.1177/18796397251399751", "claim": "The clinical trial remains ongoing, and definitive conclusions regarding clinical benefit will only be possible once the data are unblinded and fully analysed.", "cite_key": "Farag2025b", "evidence": " (, 2026); Farag M, Tabrizi SJ, Wild EJ.", "effect_size": null, "text_access": "fulltext", "study_system": "Huntington's disease clinical trials update: October 2025.", "source_cluster_id": "cluster_13", "replication_status": "independently_replicated", "claim_source_sentence": "The clinical trial remains ongoing, and definitive conclusions regarding clinical benefit will only be possible once the data are unblinded and fully analysed.", "replication_evidence_dois": [ "10.21037/jtd-2026-1-0061", "10.7759/cureus.106460" ], "effect_size_source_sentence": "At 36 months, high-dose AMT-130 met the primary endpoint, demonstrating a statistically significant 75% slowing of disease progression versus controls, as measured by the cUHDRS ( P = 0.003; mean change from baseline −0.38 vs −1.52)." }- source_refs
[ "paper:paper-03dbe55bbb2e" ]
- evidence_refs
[ { "ref": "paper:paper-03dbe55bbb2e" } ]- source_policy
{ "mode": "public_source_pointer_with_short_context", "notes": [ "Local review repositories are read-only inputs.", "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose." ], "source_commit_sha": "0632aae8abc141909207fe91f6349b9e36489c3b", "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops" }