Alterations in cortical network oscillations and parvalbumin neurons in schizop…

{
  "n": 0,
  "doi": "10.1016/j.biopsych.2015.03.010",
  "claim": "Alterations in cortical network oscillations and parvalbumin neurons in schizophrenia",
  "evidence": "Cognitive deficits are a core clinical feature of schizophrenia but respond poorly to available medications. Thus, understanding the neural basis of these deficits is crucial for the development of ne",
  "effect_size": null,
  "text_access": "abstract_only",
  "study_system": "europepmc_q6",
  "replication_status": "replication_unknown",
  "claim_source_sentence": "Here, we review 1) data from clinical studies suggesting that induction of frontal cortex gamma oscillations during tasks that engage cognitive or complex perceptual functions is attenuated in schizophrenia; 2) findings from basic neuroscience studies highlighting the features of parvalbumin-positive interneurons that are critical for gamma oscillation production; and 3) results from recent postmortem human brain studies providing additional molecular bases for parvalbumin-positive interneuron alterations in prefrontal cortical circuitry in schizophrenia.",
  "replication_evidence_dois": [],
  "effect_size_source_sentence": null
}

[
  "paper:paper-fd04a507b4b6"
]

Here, we review 1) data from clinical studies suggesting that induction of frontal cortex gamma oscillations during tasks that engage cognitive or complex perceptual functions is attenuated in schizophrenia; 2) findings from basic neuroscience studies highlighting the features of parvalbumin-positive interneurons that are critical for gamma oscillation production; and 3) results from recent postmortem human brain st...

[
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    "ref": "paper:paper-fd04a507b4b6"
  }
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