Details
- scope
- mouse, Fmr1-KO, V1, two-photon imaging + behavior
- claim_text
- Impaired perceptual learning in Fragile X model is mediated by PV neuron dysfunction and is reversible
- section_id
- section_08_evidence_package
- source_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_08_evidence_package.json
- effect_size
- reversible PV-mediated learning deficit
- review_repo
- ComputationalReviewPV
- section_ref
- wiki_page:computationalreviewpv-08
- source_kind
- review_finding
- source_path
- evidence/section_08_evidence_package.json
- source_span
- Impaired perceptual learning in a mouse model of Fragile X syndrome is mediated by parvalbumin neuron dysfunction and is reversible
- study_system
- mouse, Fmr1-KO, V1, two-photon imaging + behavior
- section_title
- In Vivo Dynamics and Behavioural Correlates
- evidence_summary
- Fmr1-KO mice show PV interneuron dysfunction that underlies atypical sensory processing; deficits in PV-mediated inhibition are causally linked to impaired perceptual learning
- review_bundle_ref
- analysis_bundle:ab-e6261c8263e7
- replication_status
- replication_unknown
- review_package_ref
- analysis_bundle:ab-e6261c8263e7
- source_artifact_ref
- wiki_page:computationalreviewpv-08
- origin_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_08_evidence_package.json
- commit_sha
- df9fc7e8d455b084152c9d713558dae0013cef21
- created_by
- persona-jerome-lecoq-gbo-neuroscience
- repository_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewPV
Raw fields (4)
- raw_fields
{ "n": 0, "doi": "10.1038/s41593-018-0231-0", "claim": "Impaired perceptual learning in Fragile X model is mediated by PV neuron dysfunction and is reversible", "evidence": "Fmr1-KO mice show PV interneuron dysfunction that underlies atypical sensory processing; deficits in PV-mediated inhibition are causally linked to impaired perceptual learning", "effect_size": "reversible PV-mediated learning deficit", "text_access": "fulltext", "study_system": "mouse, Fmr1-KO, V1, two-photon imaging + behavior", "replication_status": "replication_unknown", "claim_source_sentence": "Impaired perceptual learning in a mouse model of Fragile X syndrome is mediated by parvalbumin neuron dysfunction and is reversible", "replication_evidence_dois": [], "effect_size_source_sentence": "Impaired perceptual learning in a mouse model of Fragile X syndrome is mediated by parvalbumin neuron dysfunction and is reversible" }- source_refs
[ "paper:paper-12e52501e8c4" ]
- evidence_refs
[ { "ref": "paper:paper-12e52501e8c4" } ]- source_policy
{ "mode": "public_source_pointer_with_short_context", "notes": [ "Local review repositories are read-only inputs.", "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose." ], "source_commit_sha": "df9fc7e8d455b084152c9d713558dae0013cef21", "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV" }