Details
- scope
- mouse, V1, Otx2 conditional removal + infusion
- claim_text
- Experience-dependent transfer of Otx2 homeoprotein into PV cells regulates critical period onset for ocular dominance plasticity
- section_id
- section_08_evidence_package
- source_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_08_evidence_package.json
- effect_size
- accelerated PV-cell development and critical period timing with exogenous Otx2
- review_repo
- ComputationalReviewPV
- section_ref
- wiki_page:computationalreviewpv-08
- source_kind
- review_finding
- source_path
- evidence/section_08_evidence_package.json
- source_span
- Visual experience promoted the accumulation of non-cell-autonomous Otx2 in PV-cells, and cortical infusion of exogenous Otx2 accelerated both PV-cell development and critical period timing
- study_system
- mouse, V1, Otx2 conditional removal + infusion
- section_title
- In Vivo Dynamics and Behavioural Correlates
- evidence_summary
- Otx2 accumulates in PV cells in experience-dependent manner; exogenous Otx2 accelerates PV development and critical period; Otx2 removal abolishes plasticity
- review_bundle_ref
- analysis_bundle:ab-e6261c8263e7
- replication_status
- independently_replicated
- review_package_ref
- analysis_bundle:ab-e6261c8263e7
- source_artifact_ref
- wiki_page:computationalreviewpv-08
- origin_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_08_evidence_package.json
- commit_sha
- df9fc7e8d455b084152c9d713558dae0013cef21
- created_by
- persona-jerome-lecoq-gbo-neuroscience
- repository_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewPV
Raw fields (4)
- raw_fields
{ "n": 0, "doi": "10.1016/j.cell.2008.05.054", "claim": "Experience-dependent transfer of Otx2 homeoprotein into PV cells regulates critical period onset for ocular dominance plasticity", "evidence": "Otx2 accumulates in PV cells in experience-dependent manner; exogenous Otx2 accelerates PV development and critical period; Otx2 removal abolishes plasticity", "effect_size": "accelerated PV-cell development and critical period timing with exogenous Otx2", "text_access": "abstract_only", "study_system": "mouse, V1, Otx2 conditional removal + infusion", "replication_status": "independently_replicated", "claim_source_sentence": "Visual experience promoted the accumulation of non-cell-autonomous Otx2 in PV-cells, and cortical infusion of exogenous Otx2 accelerated both PV-cell development and critical period timing", "replication_evidence_dois": [ "10.1016/j.neuron.2013.05.016" ], "effect_size_source_sentence": "cortical infusion of exogenous Otx2 accelerated both PV-cell development and critical period timing" }- source_refs
[ "paper:paper-3140d95f7567" ]
- evidence_refs
[ { "ref": "paper:paper-3140d95f7567" } ]- source_policy
{ "mode": "public_source_pointer_with_short_context", "notes": [ "Local review repositories are read-only inputs.", "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose." ], "source_commit_sha": "df9fc7e8d455b084152c9d713558dae0013cef21", "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV" }